体型因素及组织成分对成人胸部CT水当量直径的体型特异性剂量估算的影响

姜阳; 唐文韬; 胡然; 胡勤勤; 李刚静; 张昊; 余婷; 张德川

doi:10.15953/j.ctta.2024.272

体型因素及组织成分对成人胸部CT水当量直径的体型特异性剂量估算的影响

姜阳^{1, 2,},
唐文韬²,
胡然²,
胡勤勤²,
李刚静²,
张昊²,
余婷²,
张德川^{1, 2, ,}

1.
湖南中医药大学，长沙 410208
2.
重庆市中医院，重庆 400021

基金项目: 成都中医药大学“杏林学者”医院专项（多维度个体因素对水当量直径的体型特异性成人胸部辐射剂量的影响研究（YYZX2022136））；重庆教育委员会科学技术研究计划(肝硬化肾损伤磁共振灌注成像评估（KJQN202415136））；重庆市科卫联合医学科研重点项目（基于人工神经网络的个性化成人胸部低剂量 CT 扫描模型构建及其应用研究（2024ZDXM001））；重庆自然科学基金面上项目（基于水当量直径的体型特异性成人胸部CT有效剂量估算模型的研究（cstc2021jcyj-msxmX0727))；重庆自然科学基金面上项目（基于水当量直径的体型特异性剂量估算成人胸部个性化的低剂量阈值模型研究(CSTB2023NSCQ-MSX0295））。

详细信息

作者简介:
姜阳，男，在读硕士，主管技师，主要从事胸部低剂量研究，E-mail：513515273@qq.com

通讯作者:
张德川✉，男，正高级工程师、主任技师、硕士研究生导师，主要从事CT血管造影及胸部低剂量工作，E-mail：cqggzdc@163.com。

中图分类号: TP391.41
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出版历程
- 收稿日期: 2024-11-25
- 修回日期: 2025-03-02
- 录用日期: 2025-03-04
- 网络出版日期: 2025-04-05

Impact of Individual Body Shape Factors and Tissue Contents on the Water Equivalent Diameter of Size-Specific Dose Estimations in Adult Chest CT

JIANG Yang^{1, 2,},
TANG Wentao²,
HU Ran²,
HU Qinqin²,
LI Gangjing²,
ZHANG Hao²,
YU Ting²,
ZHANG Dechuan^{1, 2, ,}

1.
Hunan University of Chinese Medicine, Changsha, Hunan 410208, China
2.
Chongqing hospital of traditional Chinese medicine, Chongqing 400021, China

摘要

摘要:
目的：探讨个体的体型因素及组织成分对成人胸部水当量直径的体型特异性剂量估算（SSDE_WED）的影响。方法：收集在本院行胸部CT平扫的成人受检者205例，采集其个体信息（身高、体重、身体质量指数）；在中间层面的横断位图像上测量胸廓的平均CT_ROI值、横断面积A_ROI、横径、前后径；测量整个扫描范围的脂肪含量、脂肪体积和肌肉含量、肌肉体积；计算前后径/横径、扫描长度、扫描长度/横径；获取受检者的容积CT剂量指数（CTDI_vol），计算出所有受检者中间层面的SSDE_WED的数值。分析脂肪含量、肌肉含量、脂肪体积、肌肉体积、BMI、横断面A_ROI、横径、前后径、扫描长度、扫描长度/横径比、前后径/横径比与SSDE_WED的相关性。结果：脂肪含量、脂肪体积、肌肉体积、BMI、横断面A_ROI、横径、前后径、扫描长度/横径比与SSDE_WED有显著正相关性；肌肉含量、前后径/横径比值、扫描长度与SSDE_WED无相关性。结论：多种个体体型因素及组织成分与SSDE_WED有显著相关性，其中脂肪组织是影响SSDE_WED的关键的因素。
- 水当量直径 /
- 容积CT剂量指数 /
- 体型特异性辐射剂量估算 /
- 脂肪含量
Abstract:
Objective: To investigate the impact of individual body size factors and tissue composition on the size-specific dose estimate(SSDE_WED) based on water equivalent diameter for adult chest. Methods: A total of 205 adult subjects who underwent chest CT scans at our hospital were enrolled, and their individual information (height, weight, body mass index) was collected. The average CT_ROI value, cross-sectional area A_ROI, transverse diameter, and anteroposterior diameter of the thorax on the axial images at the intermediate level were collected. The fat content, fat volume, muscle content, and muscle volume across the entire scanning range were recorded. The anteroposterior diameter/transverse diameter, scan length, and scan length/transverse diameter were calculated. The volume CT dose index (CTDI_vol) of the subjects was obtained, and the SSDE_WED values at the mid-level of all subjects were calculated. The correlations between fat content, muscle content, fat volume, muscle volume, BMI, cross-sectional A_ROI, transverse diameter, anteroposterior diameter, scan length, scan length/transverse diameter ratio, anteroposterior diameter/transverse diameter ratio, and SSDE_WED were analyzed. Results: Fat content, fat volume, muscle volume, BMI, cross-sectional AROI, transverse diameter, anteroposterior diameter, scan length/transverse diameter ratio are significantly positively correlated with SSDEWED. Muscle content, anteroposterior/transverse diameter ratio, and scan length showed no correlation with SSDE_WED. Conclusion: Multiple individual body size factors and tissue compositions are significantly correlated with SSDE_WED, among which adipose tissue is the key factor influencing SSDE_WED.
- water equivalent diameter /
- volume CT dose index /
- size-specific radiation dose estimation /
- fat content

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图 1 胸部CT定量参数的测量

注：（a）在原始中间层面横断位图像上测量前后径及横径分别是397.9 mm和268.6 mm；（b）其横断面感兴趣区（ROI）的面积为81208.8 mm²；（c）脂肪含量测定，选取脂肪CT值范围（−150~-50 HU），脂肪体积为5537.81 cc，脂肪含量为25.3%；（d）肌肉含量测定，选取肌肉CT值范围（35~50 HU），肌肉体积为2176.24 cc,肌肉含量为9.9%。

Figure 1. Measurement of quantitative parameters of chest CT

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表 1 205例受检者一般资料

Table 1 General information of 205 subjects

项目	数值	项目	数值
例数	205	脂肪含量/（%，$\bar x\pm s $）	16.41±3.37
性别[n(%)]		肌肉含量/（%，$\bar x\pm s $）	9.10±1.79
男	104（50.7）	A_ROI/（mm²，$\bar x\pm s $）	63299.66±9965.31
女	101（49.3）	横径/（mm，$\bar x\pm s $）	336.07±27.74
年龄/（岁，$\bar x\pm s $）	56.45±16.64	前后径/（mm，$\bar x\pm s $）	226.51±23.42
身高/（mm，$\bar x\pm s $）	162.56±7.91	纵径/（mm，$\bar x\pm s $）	302.41±30.67
体重/（kg，$\bar x\pm s $）	63.53±12.42	横径/前后径（$\bar x\pm s $）	0.67±0.05
BMI/（m/kg²，$\bar x\pm s $）	23.90±3.46	扫描长度/横径（$\bar x\pm s $）	0.906±0.12
脂肪体积/（cc，$ x\pm s $）	3243.19±3243.19	CT_ROI/（HU，$ x\pm s $）	−297.46±59.92
肌肉体积/（cc，$\bar x\pm s $）	1751.33±507.79	SSDE_WED（$ x\pm s $）	29.533±6.99

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表 2 SSDE_WED与脂肪含量、肌肉含量、脂肪体积、肌肉体积、BMI的相关性

Table 2 The correlation between SSDE_WED and fat content, muscle content, fat volume, muscle volume, and BMI

相关因素	平均值	SSDE_WED
相关因素	平均值	r	P
脂肪含量	16.413±3.375	0.851^**	< 0.01
肌肉含量	9.101±1.789	0.106	0.132
脂肪体积	3243.189±929.366	0.741^**	< 0.01
肌肉体积	1751.322±507.784	0.615^**	< 0.01
注：**表示P < 0.01（双尾），相关性非常显著。

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表 3 SSDE_WED与扫横断面A_ROI、横径、前后径、扫描长度、扫描长度/横径、前后径/横径的相关性

Table 3 The correlation between SSDE_WED and A_ROI, transverse diameter, anteroposterior diameter, scanning length, scanning length/transverse diameter, and anteroposterior diameter/transverse diameter

相关因素	平均值	SSDE_WED
相关因素	平均值	r	P
横断面A_ROI	63299.653±9965.309	0.822^**	< 0.01
横径	336.066±27.736	0.788^**	< 0.01
前后径	226.507±23.420	0.710^**	< 0.01
扫描长度	302.410±30.665	0.058	0.407
扫描长度/横径	0.906±0.122	−0.445^**	< 0.01
前后径/横径	0.675±0.004	0.072	0.307
BMI	23.904±3.463	0.745^**	< 0.01
注：**表示P < 0.01（双尾），相关性非常显著。

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