Research Progresses of CT in Interstitial Lung Abnormalities
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摘要:
肺间质异常（ILAs）是一种CT上偶然发现的非特异性间质改变，主要表现为磨玻璃影、网状结构或牵拉性支气管扩张等异常表现。随着胸部影像技术的普及以及人口老龄化加剧，ILAs检出率显著提高，它与年龄和吸烟呈正相关，有进展的风险，以多种方式影响患者健康，部分ILAs将可能进展为肺间质疾病（ILD）或伴肺功能下降。但目前人们对其诊断标准、发生机制、评价管理等认识仍存在不足和争议。本文将系统综述近年来ILAs研究的关键进展。
Abstract:Interstitial lung abnormalities (ILAs) are non-specific interstitial changes incidentally found on CT scans, mainly presenting as ground-glass opacities, reticular structures, or traction bronchiectasis. With the popularization of chest imaging techniques and the aging of the population, the detection rate of ILAs has significantly increased. It is positively correlated with age and smoking, has the risk of progression, and affects patients' health in various ways. Some ILAs may progress to interstitial lung disease (ILD) or be accompanied by a decline in lung function. However, there are still deficiencies and controversies in people's understanding of its diagnostic criteria, occurrence mechanism, evaluation, and management. This article systematically reviews the key progress in ILAs research in recent years.
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[1] HATABU H, HUNNINGHAKE G M, RICHELDI L, et al. Interstitial lung abnormalities detected incidentally on CT: A position paper from the Fleischner Society[J]. Lancet Respiratory Medicine, 2020, 8(7): 726-737. DOI: 10.1016/S2213-2600(20)30168-5.
[2] ZHANG Y C, WAN H J, RICHELDI L, et al. Reticulation is a risk factor of progressive subpleural nonfibrotic interstitial lung abnormalities[J]. American Journal of Respiratory and Critical Care Medicine, 2022, 206(2): 178-185. DOI: 10.1164/rccm.202110-2412OC.
[3] PUTMAN R K, GUDMUNDSSON G, AXELSSON G T, et al. Imaging patterns are associated with interstitial lung abnormality progression and mortality[J]. American Journal of Respiratory & Critical Care Medicine, 2019, 200(2): 175-183.
[4] CHUA F, DESAI S R, NICHOLSON A G, et al. Pleuroparenchymal fibroelastosis. A review of clinical[J]. Radiological, and Pathological Characteristics. Annals of the American Thoracic Society, 2019, 16(11): 1351-1359.
[5] RICE M B, LI W Y SCHWARTZ J, et al. Ambient air pollution exposure and risk and progression of interstitial lung abnormalities: The Framingham heart study[J]. Thorax, 2019, 74(11): 1063-1069. DOI: 10.1136/thoraxjnl-2018-212877.
[6] HATA A, HINO T, YANAGAWA M, et al. Interstitial lung abnormalities at CT: Subtypes, clinical significance, and associations with lung cancer[J]. Radiographics. 2022, 42(7): 1925-1939.
[7] WALSH SIMON L F, RICHELDI L. Subclinical interstitial lung abnormalities: Lumping and splitting revisited[J]. American Journal of Respiratory and Critical Care Medicine. 2019, 200(2): 121-123.
[8] HOYER N, THOMSEN L H, WILLE M M W, et al. Increased respiratory morbidity in individuals with interstitial lung abnormalities[J]. BMC Pulmonary Medicine, 2020, 20(1): 67. DOI: 10.1186/s12890-020-1107-0.
[9] PUTMAN R K, HATABU H, ARAKI T, et al. Association between interstitial lung abnormalities and all-cause mortality[J]. Jama-Journal of The American Medical Association, 2016, 315(7): 672-681. DOI: 10.1001/jama.2016.0518.
[10] HATA A, YANAGAWA M, MIYATA T, et al. Association between interstitial lung abnormality and mortality in patients with esophageal cancer[J]. Japanese Journal of Clinical Oncology. 2024, 42(8): 841-851.
[11] LEE T S, JIN K N, LEE H W, et al. Interstitial lung abnormalities and the clinical course in patients with COPD[J]. Chest, 2021, 159(1): 128-137. DOI: 10.1016/j.chest.2020.08.017.
[12] ZHENG J R, GUO J X, WANG G D, et al. Interstitial lung abnormality in COPD is inversely associated with the comorbidity of lung cancer[J]. BMC pulmonary medicine, 2024, 24(1): 506-518. DOI: 10.1186/s12890-024-03311-3.
[13] WHITTAKER B S A, PADILLA M, MHANGO G, et al. Interstitial lung abnormalities and lung cancer risk in the national lung screening trial[J]. Chest, 2019, 156(6): 1195-1203. DOI: 10.1016/j.chest.2019.06.041.
[14] AXELSSON G T, PUTMAN R K, ASPELUND T, et al. The associations of interstitial lung abnormalities with cancer diagnoses and mortality[J]. European Respiratory Journal, 2020, 56(6).
[15] IM Y, PARK H Y, SHIN S, et al. Prevalence of and risk factors for pulmonary complications after curative resection in otherwise healthy elderly patients with early stage lung cancer[J]. Respiratory Research, 2019, 20(1): 136. DOI: 10.1186/s12931-019-1087-x.
[16] NAKANISHI Y, MASUDA T, YAMAGUCHI K, et al. Pre-existing interstitial lung abnormalities are risk factors for immune checkpoint inhibitor-induced interstitial lung disease in non-small cell lung cancer[J]. Respiratory Investigation, 2019, 57(5): 451-459. DOI: 10.1016/j.resinv.2019.05.002.
[17] LI F J, ZHOU Z Y, WU A L, et al. Preexisting radiological interstitial lung abnormalities are a risk factor for severe radiation pneumonitis in patients with small-cell lung cancer after thoracic radiation therapy[J]. Radiation Oncology (London, England), 2018, 13(1): 82. DOI: 10.1186/s13014-018-1030-1.
[18] MILLER E R, PUTMAN R K, VIVERO M, et al. Histopathology of interstitial lung abnormalities in the context of lung nodule resections[J]. American Journal of Respiratory and Critical Care Medicine, 2018, 197(7): 955-958. DOI: 10.1164/rccm.201708-1679LE.
[19] CHAE K J, CHUNG M J, JIN G Y, et al. Radiologic-pathologic correlation of interstitial lung abnormalities and predictors for progression and survival[J]. European Radiology, 2022, 32(4): 2713-2723. DOI: 10.1007/s00330-021-08378-8.
[20] HAN X Y, FAN Y Q, ALWALID O, et al. Fibrotic interstitial lung abnormalities at 1-year follow-up CT after severe COVID-19[J]. Radiology, 2021, 301(3): E438-E440. DOI: 10.1148/radiol.2021210972.
[21] PUTMAN R K, AXELSSON G T, ASH S Y, et al. Interstitial lung abnormalities are associated with decreased mean telomere length[J]. European Respiratory Journal, 2022, 60(2).
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