ISSN 1004-4140
    CN 11-3017/P

    基于U-HRCT的成人内耳核心结构定量解剖学参数参考值研究

    Reference Values of Quantitative Anatomical Parameters of Core Adult Inner Ear Structures Based on U-HRCT

    • 摘要: 目的:为进一步丰富国人内耳精细解剖的影像学量化参考资料,本研究基于超高分辨力CT(ultra-high resolution CT,U-HRCT),通过手工标注与测量,建立内耳关键结构(耳蜗、前庭、半规管及总脚)16项核心结构定量解剖学参数的正常参考值范围。方法:回顾性纳入113例无中耳、内耳及颞骨病变的成人受检者颞骨U-HRCT影像资料(共226耳),由2名影像诊断医师使用专业软件逐层标注内耳6个关键结构并三维重组,测量16项核心结构参数,采用组内相关系数(Intraclass Correlation Coefficient,ICC)评估观察者间一致性,采用多重线性回归分析年龄、性别、侧别对参数的独立影响;采用百分位数法建立95%参考区间。结果:所有参数观察者间ICC值均>0.85,测量一致性优异、可靠性高;首次建立U-HRCT下内耳16项核心结构定量解剖学参数的95%参考区间。多重线性回归分析显示,性别是内耳参数的主要独立影响因素,多数耳蜗、前庭及半规管参数存在显著性别差异;年龄与侧别对内耳形态学结构无影响。结论:本研究建立的内耳核心结构定量参数参考值数据库可靠可复现,可为内耳自动分割算法验证提供标准化参考,为耳科精准手术规划、内耳疾病研究及解剖机制探索提供量化依据,推动国人内耳影像评估向系统化、定量化发展。

       

      Abstract: Objective: To further enrich quantitative imaging reference data for the fine inner ear anatomy of the Chinese population, this study aimed to establish the 95% normal reference values of 16 core quantitative anatomical parameters of key inner ear structures (cochlea, vestibule, semicircular canals, and common crus), based on ultra-high resolution computed tomography (U-HRCT), using manual labeling and quantitative measurement. Methods: U-HRCT images of the temporal bone were collected from 113 adults free of middle ear, inner ear, and temporal bone lesions. Two radiologists performed slice-by-slice delineation of six key inner ear structures using professional software, followed by three-dimensional reconstruction. Sixteen core structural parameters were then measured. The intraclass correlation coefficient (ICC) was used to assess inter-observer reliability. Multiple linear regression analysis was used to explore the independent effects of age, sex, and laterality on these parameters. The percentile method was used to establish 95% reference intervals. Results: All interobserver ICC values were >0.85, reflecting excellent measurement consistency and high reliability of the data. The 95% reference values of the 16 U-HRCT-derived inner ear quantitative parameters were established for the first time. Multiple linear regression analysis showed that sex was the main independent influencing factor for inner ear parameters, and most cochlear, vestibular, and semicircular canal parameters had significant sex-associated discrepancies. Age and laterality did not have a significant effect on the morphological structure of the inner ear. Conclusion: The constructed database of quantitative reference values for pivotal inner ear structures is robust and reproducible. It can serve as a standardized ground truth to validate automated inner ear segmentation algorithms, to obtain quantitative evidence for precision otosurgical planning, for inner ear pathological studies and anatomical mechanistic investigations, and to facilitate the systematization and quantitative transformation of inner ear imaging assessment in the Chinese population.

       

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