Contrast Agents for Computed Tomography Based on Gold Nanoparticles
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摘要: 金纳米颗粒有着优异的表面性质,成熟的制备路线和良好的生物相容性。目前临床通常使用的CT商用造影剂是含碘的有机分子。金与碘相比,有着更高的原子序数和X射线吸收系数。随着纳米材料和生物纳米技术的发展,近年来,在金纳米颗粒作为CT造影剂方面涌现出一系列优秀的工作成果。本文综述了金纳米颗粒的制备路线,表面修饰,以及X射线造影情况,重点介绍包裹了PEG、阿拉伯树胶、钆螯合物、高密度脂蛋白等的金纳米颗粒CT造影剂的试用情况,并对金纳米棒颗粒用作CT造影剂存在的问题和应用前景进行讨论。Abstract: Gold nanoparticles hold excellent surface properties,multiple synthestic routes and good biocompatibility.Currently,the commercial clinical Computed Tomography(CT)contrast agents are iodine based organic molecules.Compared with iodine,Gold has a larger atomic number and X-ray absorption coefficient.In recent years,quite a few works about using gold nanoparticles as CT contrast agents have been published.In this review,We outlined the synthesis routes,surface modification,and the behaviors of gold nanoparticles as CT contrast agents.We emphasized the tryout of PEG,gum arabic,gadolinium chelate,and high-density lipoproteins etc.as surfactant to coat gold nanoparticles for CT imaging.We also discussed the existent problems of the newly developed contrast agents and looked forward to the future of them.
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Keywords:
- gold nanoparticle /
- CT /
- contrast agent
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期刊类型引用(2)
1. 杨政君,张昂,陈勇,姜江,王凌云,张勇,张璇,齐晓凤. 辐射剂量和管电压对CT图像质量的影响:基于任务的图像质量评价. CT理论与应用研究. 2022(02): 211-217 . 本站查看
2. 陈思敏,林怀雄,刘昌华,彭晋,林建坤. 小剂量CT扫描技术结合迭代重建算法在下肢静脉血管成像中的应用. 医疗装备. 2019(15): 33-34 . 百度学术
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