Abstract: Objective: To investigate the osteoporosis compression fracture percutaneous vertebral plasty (PVP) injured vertebral height change of multi-slice CT (MSCT) and clinical evaluations. Methods: 25 cases of osteoporosis vertebra compression fractures was by MSCT examination confirmed, preoperative simulation puncture path on CT image and select PVP puncture method, statistical analysis was carried out on the image data and clinical data, from the MSCT and clinical curative effect evaluation. Results: This group of patients with unilateral vertebral arch puncture success rate 92%, significantly reduce the lumbar pain after surgery. There is significant statistical difference in pre and post PVP vertebral compression ratio, Cobb's Angle and visual analogue scale, there were no significant difference in vertebral compression ratio, Cobb's Angle and visual analogue scale after six months follow-up data's. Conclusions: MSCT can provide accurate anatomic data for PVP in the selection of puncture needle and puncture path, can help improve PVP clinical effect, and can provide important clinical information in postoperative follow-up.