Abstract: Seismic reflection travel time picking is the primary part of reflection travel time tomography. In this paper, we propose a reflection travel time picking method based on multi-domain human-computer interaction, which includes common shot point domain, common receiver point domain, common middle point domain, and common offset domain. By analyzing various characteristics of the seismic data in different domains, we choose to pick reflection travel time in the different domain. In the human-computer interaction environment, the combination of interpreter and computer can help to improve accuracy and efficiency of the picking. Using Qt programming language, we have realized multi-domain display and travel time picking software for seismic data. Both results from synthetic and the field seismic data indicate that the software is flexible and easy to operate, and good results of travel time picking can still be achieved for seismic data acquired in complex areas.