Abstract: Objective: To discuss appearance of solitay plasmacytoma of spine(SPS) using Multi-slice computed tomography(MSCT) and promote the cognition of this disease. Methods: Combination with literature, one case with pathologically proved SPS and clinical data as well as the image features of MSCT was retrospective reviewed. Results: The imaging features of SPS is that residual crest bone with linear, wedge and irregular-shaped in centrum bone destruction area. This case show fractured vertebral endplate with multiple crack sample and one side accessories involved, vertebral body and accessories display expansion bone destruction, and soft tissue mass adjacent to vertebral body. MSCT can visually display imaging features of SPS lesions. Conclusion: MSCT can clear display imaging features of SPS lesions and higher diagnostic value to SPS.