Abstract: Objective: To study manifestations of hepatic multilocular and ring-enhancement lesions and differential diagnosis of liver abscess, intrahepatic cholangiocarcinoma and liver metastasis. Methods: Imaging findings of 31 cases were retrospectively analyzed, including liver abscess 15 cases, intrahepatic cholangiocarcinoma 7 cases and liver metastasis 9 cases. 13 cases carry the CT plain scan and three phases enhanced examination of upper abdominal. 7 cases underwent MRI plain scan and LAVA multiphase scanning. 11 patients underwent CT and MRI examination meanwhile. Results: There was a statistical difference among the three multilocular and ring-enhancement lesions for the enhancement signs of the morphology of ring wall and septum. The ring-wall and septum thickness uniformity, complete enhancement(P < 0.05), and the appears mass diminution sign(P < 0.05).The ring enhancement in a centripetal filling(P < 0.05) or retraction of liver capsule(P < 0.05) and expansion of bile duct wall local thickening, the findings is helpful to diagnosis cholangiocarcinoma. The ring-wall irregular interrupt or enhancing wall nodule, it has great value for diagnosis for liver metastasis. Conclusions: The three lesions have their imaging features, combine with CT and MRI have a high value for differentia diagnosis of the three lesions.