Abstract: Objective: To evaluate the value of CT-guided percutaneous RFA therapy of lung tumours and analyze complications. Methods: Fourty-eight patients with pathologically proved lung neoplasms that comprised 43 primary lung cancers initially underwent CT-guided percutaneous RFA treatment and subsequently the near-term efficacy. Results: Our experiments have indicated an initial increase in lesion size at immediate follow-up CT. The density of 54 lesions was lowered. Among total 54 lesions of 48 patients, RFA resulted in complete necrosis of 54 lesions, which appears as devascularization and enhancement of residual tumors on postcontrast CT images. Radiologically assessed through measurements of the lesions on axial CT scans in the lung window setting lesions had CR 61%(33/54) and PR 39%(21/54) at 3 month follow-up. No severe complications related to the procedure occurred in the group patients. Conclusion: CT-guided percutaneous RFA in treating lung neoplasms is safe and effective, which has recently received wide attention for the promising results achieved, and can serve as a new approach to the treatment of lung neoplasm.