A Preliminary Study of Correlation between Dynamic Contrast Enhancement MRI and 18F-FDG PET/CT in Small Peripheral Lung Cancer
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摘要: 目的:探讨周围型小肺癌动态增强磁共振成像(DCE-MRI)定量参数和18F-2-脱氧葡萄糖正电子体层摄影/计算机体层摄影(18F FDG PET/CT)最大标准摄取值(SUVmax)的相关性。方法:27例最大径 ≤ 3 cm的周围型小肺癌行18F FDG PET/CT及动态增强MR扫描。测量磁共振定量参数容量转运常数(Ktrans)、回流速率常数(Kep)、细胞外对比剂容积分数(Ve)及PET/CT最大标准摄取值(SUVmax)。比较动态增强MRI三个定量参数值与SUVmax的相关性。结果:DCE-MRI的定量参数Ktrans值、Kep值分别与PET/CT半定量参数SUVmax之间存在正相关(P<0.05);而Ve与SUVmax无相关性(P>0.05)。结论:DCE-MRI定量参数Ktrans值及Kep值与SUVmax正相关,三者可共同反映周围型小肺癌的恶性特征。
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关键词:
- 周围型肺癌 /
- 体层摄影术 /
- X线计算机 /
- 灌注 /
- 正电子发射体层摄影术
Abstract: Objective: To investigate the correlations of the dynamic contrast enhancement MRI (DCE-MRI) and glucose metabolism determined by the maximum standardized uptake value (SUVmax) at 18F-FDG PET/CT in small peripheral cell lung cancer. Methods: 18F-FDG PET/CT and DCE-MRI wereperformed in 27 consecutive patients with histologically verifiedsmall peripherallung cancer (maximal diameter ≤ 3 cm). The quantitative MR pharmaeokineticparameters including Ktrans, Kep, Ve and SUVmax were measured. Pearson's correlations were conducted between the three MR parameters and SUVmax.Results: Positive correlations were found between Ktrans and SUV max, Kep and SUVmax (P < 0.05). No significant correlation was found for thecomparison of Ve and SUV max (P>0.05). Conclusions: Positive correlationswere found between Ktrans and SUVmax, Kep and SUVmax. Combination of three parameters can reflect the malignant feature of lung cancer.-
Keywords:
- peripheral lung cancer /
- tomography /
- X-ray computed /
- perfusion /
- positron emission tomography
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期刊类型引用(6)
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