Abstract: Objective: To investigate the clinical value of MRI in the diagnosis and differential diagnosis of cystic lesions of the pancreas. 60 patients with pancreatic cystic lesions methods in our hospital from January 2013 to December 2016 were based on the inspection methods of these cases, patients were divided into MRI group and CT group, compared to two groups of patients, examination results and pathological examination results examination time for statistical analysis. Results papillary myxoma and pathological diagnosis of MRI pseudocyst, cyst, cystadenoma, cystadenocarcinoma, intraductal, malignant islet cell tumor, solid thyroid papilloma coincidence rate was 100.0% (13/13), 100.0% (16/16), 91.7% (11/12), 100.0% (7/7), 100.0% (6/6), 100.0% (3/3), 100.0% (3/3), CT diagnosis and pathological coincidence rate was 84.6% (11/13), 93.8% (15/16), 100.0% (12/12), 85.7% (6/7), 83.3% (5/6), 66.7% (2/3), 100.0% (3/3). The difference of MRI, CT diagnosis and pathological coincidence rate was significant (P > 0.05). The MRI group was significantly longer than that in group CT (P < 0.05). Conclusion MRI diagnosis and differential diagnosis of pancreatic cystic lesions have certain advantages compared with CT, although MRI has a long time to check, but it can have multiple imaging, meanwhile can provide more information on the clinical analysis of cystic components, In particular, more sensitive to the size, number, range, extent, composition, nature, etc. of bleeding and cystic lesions.