Abstract: Objective: To explore the relationship among epicardial adipose tissue (EAT), pericardial adipose tissue (PAT) and carotid artery plaque. Methods: The routine health check-up data of 475 senior managers in Kailuan Corporation were collected and analyzed. All of them underwent chest CT scan examination, EAT and PAT volume were measured, according to the carotid ultrasound, the health check-up data was divided into plaque group (165 cases) and non-plaque group (310 cases), based on BMI, taking BMI < 24 as normal weight group, 24 ≤ BMI < 28 as overweight group, BMI ≥ 28 as obesity group, moreover, the correlation of EAT and PAT volume in normal weight group, overweight and obesity group with or without carotid plaque was studied respectively. Results: There were 45 cases with carotid plaques and 84 cases without plaques in normal weight group, 86 subjects with carotid plaques and 172 subjects without carotid plaques in overweight group, obesity group included 34 cases with carotid plaques and 54 cases without carotid plaques, the EAT and PAT volume of the subjects with carotid plaques in three groups were higher than those without carotid plaques (P < 0.05). Conclusion: EAT and PAT increase with obesity. After adjusting BMI, the EAT and PAT volume have a strong correlation with the formation of carotid plaques.