Objective: To compare the value of the application of multi-slice spiral CT and echocardiography in the diagnosis of emergency aortic dissection. Methods: From December 2014 to December 2016, 61 patients with acute aortic dissection diagnosed by CT angiography in our hospital were retrospectively analyzed. All patients were examined by echocardiography and multi-slice spiral CT, and comparative analysis of two groups of diagnostic results. Results: Of all 61 patients with aortic dissection, 61 had a general abnormality, 41 had aortic valve abnormalities, 44 had aortic arch abnormalities, 45 had abnormal thoracic and abdominal aorta, and 6 had coronary artery abnormalities. The diagnosis of thoracic and abdominal aorta abnormalities and coronary artery abnormalities were 100.00%, which were 91.80%, 86.67% and 0.00% higher than those of echocardiography, the difference was statistically significant (P
< 0.05). There was no significant difference between the two groups in the diagnosis of aortic valve abnormalities and aortic arch abnormalities (P
> 0.05). Conclusion: Echocardiography in the diagnosis of aortic dissection is non-invasive, reproducible, and easy to operate. It can be used for the diagnosis of aortic arch abnormalities, Debakey type I aortic valve with high accuracy. Multi slice spiral CT has more advantages than echocardiography, which can be used to diagnose the abnormal branches of thoracic and abdominal aorta, coronary artery anomalies and so on.