MRI Technique for Diagnosis of Cerebral Ischemic Foci and Evaluation of Alzheimer's Disease
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摘要: 目的：探讨磁共振成像（MRI）技术诊断脑缺血灶、脑萎缩合并缺血灶中的应用及对阿尔茨海默氏症（AD）的风险评估。方法：选取2016年1月至12月我院体检人员40例为A组，收治的缺血灶患者40例为B组，脑萎缩合并缺血灶患者40例为C组，阿尔茨海默氏症患者40例为D组，应用MRI评估各组患者MRI图像的差异。结果：C组研究对象的颈内动脉︰舒张期流速（ICA︰PDV）、R-ICA︰MF显著低于A组及B组，ICA︰收缩期流速（PSV）显著低于B组，差异均有统计学意义（P<0.05），但与D组相比无统计学差异；C组研究对象的L-IJV：PDV指标显著低于A组及B组，差异均有统计学意义（P<0.05）；但与D组差异无统计学意义；4组研究对象的MRI厚度方面在眶额皮质（OFC）、后扣带回皮层（PCC）、左半球内嗅皮层（EC）及右半球PCC线性趋势等均存在显著区别（P<0.05）。结论：缺血灶和脑萎缩是脑组织病理改变不同阶段的结果，MRI诊断的准确度较高，并且脑萎缩合并缺血灶患者和AD患者MRI图像相似，提示脑缺血灶合并脑萎缩合并发生AD风险，对临床有重要的指导价值。Abstract: Objective: To evaluate the application of MRI(magnetic resonance imaging) in the diagnosis of cerebral ischemic foci and brain atrophy and ischemic foci and the assessment of the risk of Alzheimer's disease(AD). Methods: 40 health people as group A, 40 patients with ischemic foci were group B, 40 patients with cerebral atrophy and ischemic foci and 40 AD patients were enrolled in our hospital from January 2016 to December 2016. All the cases were examiningd with MRI Diagnose and evaluate the differences in MRI images. Results: The ICA:PDV, R-ICA:MF of group C were significantly lower than those of group A and group B(P<0.05), ICA:PSV of group C was significantly lower than group B(P<0.05), but there were no significantly difference(P>0.05). The L-IJV:PDV of group C were significantly lower than in group A and group B(P<0.05). The MRI thickness of the four groups was significantly higher than that of the control group(P<0.05). The MRI thickness of the three groups was significantly higher than that of the control group(P<0.05), and the difference was statistically significant(P<0.05) Olfactory cortex(EC) and right hemisphere PCC linear trend were significantly different(P<0.05). Conclusion: Ischemic foci and brain atrophy are the result of different stages of brain tissue pathological changes.MRI diagnostic accuracy is higher, and the merge focal ischemic brain atrophy patients MRI images are similar to AD patients, and it can suggest the risk of AD, which has important clinical guiding value.
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期刊类型引用(3)
1. 阿迪力·阿布来提，阿不都克尤木·阿不拉，邹科，马依迪丽·尼加提，戴国朝，田序伟. PC-MRI技术在单纯性脑缺血灶中的初步应用. 影像研究与医学应用. 2021(03): 15-17 . 
百度学术
2. 曹和琴，宣海仙，胡宗科. 血清miR-26b-5p作为阿尔茨海默病的潜在治疗靶点的研究. 中国医师杂志. 2021(11): 1718-1720 . 百度学术
3. 江敏智. 脑缺血灶和脑梗死的CT磁共振成像检查的影像特征比. 人人健康. 2019(22): 256-257 . 百度学术
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