The Study of 3D-ASL in Assessing Cerebral Blood Flow in Normal Persons
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摘要: 目的：研究磁共振三维动脉自旋标记（3D-ASL）技术测量正常人的脑血流量的可行性、准确性。方法：将63名健康志愿者分成两组，其中以60岁为分界线，A组（<60岁，共33人，平均年龄36岁，其中男性14，女性19人；B组（≥ 60岁）共30人，平均年龄69岁，其中男性12人，女性18人。采用常规MRI、ASL及3D T1序列进行检查，经图像后处理得到血流量（CBF）图，将CBF伪彩图与3D-T1序列相匹配，分别测量各部位的脑CBF值，利用方差分析法分析CBF值与年龄、男女不同性别以及部位之间的关系。结果：右侧额叶、顶叶的CBF值比左侧的高，但其他部位左右两侧CBF值之间的差异无统计学意义（P>0.05）；A组的平均值比B组的平均值要高；男性的CBF值比女性的CBF值低。不同部位CBF值之间的差异有统计学意义（P<0.05）。结论：ASL能够评估正常人的脑血流量，年龄、性别和部位对CBF值的测量有显著影响。Abstract: Objective: With the increasing incidence of stroke which is due to the reduction of cerebral blood flow, the quantitative measurement of cerebral blood flow is very important. There are a variety of quantitative detection methods of cerebral blood flow, the commonly used quantitative detection methods are PET and SPECT, but there is radiation of the above detection methods, and the operation is complex. The purpose of this study is to measure cerebral blood flow of normal persons by three-dimensional magnetic resonance arterial spin labeling technique (3 D-ASL). Methods: Sixty-three health persons, who were divided into group A (< 60 years) and group B (≥ 60 years) according to age. The average age of group A was 36 years (including 14 males and 19 females), the average age of group B was 69 years (including 12 males and 18 females), accepted examinations including routine MRI, 3 D-T1 and 3 D-ASL sequences. We got the cerebral blood flow maps and matched it with the 3 D-T1 images. The CBF values of every part of brain were measured, and the variance analysis method was used to compare the CBF values of every lobe, basal ganglia and cerebral hemisphere between the two groups. Results: There was significant differences of the CBF values in frontal lobe and parietal lobe between left and right hemispheres in two groups (P<0.05). A significant difference of the CBF values of bilateral cerebral hemispheres, frontal lobe, parietal lobe, temporal lobe, occipital lobe and basal ganglia was found between group A and group B (P<0.05). The average value of group A was higher than that of group B. The CBF values of bilateral cerebral hemispheres of female group were significantly higher than that of male group. There was a significant difference among the frontal lobe, parietal lobe, temporal lobe, occipital lobe and basal ganglia of CBF value in the same person (P<0.05). Conclusion: The 3 D-ASL can be used to evaluate the cerebral blood flow in health persons, and the CBF value was significantly affected by age, gender and location.
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