The Application of DTI and SWI for Substantia Nigra in Early Primary Parkinson's Disease
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摘要: 目的：探讨磁共振扩散张量成像（DTI）及磁敏感加权成像（SWI）在早期原发性帕金森病（PD）患者脑黑质改变中的应用价值。方法：采用3.0 T磁共振成像系统对早期原发性PD患者组及正常对照组进行常规序列、DTI及SWI序列扫描，其中原发性早期PD患者13例，正常对照组13例。测量两组间脑黑质的FA值、ADC值及黑质致密带大小。结果：两组间双侧黑质的FA值比较，PD组较对照组减低，差异有统计学意义（P<0.05）。两组间黑质ADC值比较，差异无统计学意义P>0.05）。PD组黑质致密带大小较对照组减小，差异有统计学意义（P<0.05）。结论：黑质的FA值及黑质致密带大小有助于PD的早期诊断，DTI与SWI具有协同作用，可为PD的早期诊断提供有价值的线索。Abstract: Objective: To investigate the application of diffusion tensor imaging (DTI) and susceptibility weighted imaging (SWI) in the changes of substantia nigra in patients with early primary Parkinson's disease. Methods: Conventional sequence, DTI, and SWI scans were performed on 13 patients with early primary Parkinson's disease and 13 volunteers as controls using a 3 T magnetic resonance imaging system. The FA and ADC values of the substantia nigra of the two groups and the size of the substantia nigra pars compacta were measured. Results: The FA values of bilateral substantia nigra were reduced in the PD group compared with the control group, the difference was statistically meaning (P<0.05). There was no significant difference in the ADC values of the substantia nigra between the two groups (P>0.05). The size of the substantia nigra pars compact in the PD group was smaller than that in the control group, the difference was statistically meaning (P<0.05). Conclusions: The FA value of the substantia nigra and the size of the substantia nigra pars compacta contribute to the early diagnosis of PD. DTI and SWI have a synergistic effect and may provide valuable clues for the early diagnosis of PD.
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期刊类型引用(3)
1. 董家科，邓敏，王禄马，杨涛，迪力夏提·艾热提，阿娜努尔·麦麦提亚森. 双能X线骨密度扫描诊断早期偏侧性帕金森病的临床价值. 中国医刊. 2023(03): 324-327 . 
百度学术
2. 董家科，邓敏，杨涛，孔许强，刘康永，蔡思鹏，王涛，姆妮热·亚力昆. 扩散峰度成像对早期帕金森病患者黑质微观结构变化的研究. CT理论与应用研究. 2022(05): 623-629 . 本站查看
3. 陆健美，贾中正，马松华，赵秀平. “燕尾征”在原发性帕金森病患者中的诊断效果及临床治疗指导价值研究. 当代医学. 2020(32): 1-3 . 百度学术
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