Abstract: Objective: To discuss the image quality of HCC based on the angiographic parameters of two types of angiocatheter, i.e. COOK MEDICAL RH angiocatheter and TERUMO MEDICAL RH angiocatheter. Methods: 40 cases (23 males, 17 females) of TACE in the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine from June 2018 to January 2019 were selected. Patients ranged from 30 to 75 years with an average age of 56.3 and were all diagnosed with HCC. The actual imaging pressure of celiac trunk and superior mesenteric artery angiography in two groups of patients was analyzed and the image quality was evaluated under the same parameter settings, machinery and image post processing software with 20 cases using COOK MEDICAL RH angiocatheter (the COOK group) and 20 cases using TERUMO MEDICAL RH angiocatheter (the TERUMO group). Results: Among 340 angiography images of 40 cases, 36 cases showed good image quality with 16 from the COOK group and 20 from the TERUMO group, 4 cases showed poor image quality with all from the COOK group. The data was processed and analyzed with SPSS 25.0 software. The mean value of actual pressure of celiac trunk angiography was 107.6 PSI in the COOK group and 93.1 PSI in the TERUMO group, the difference was statistically significant (P<0.05), while that of the superior mesenteric artery angiography was 101.4 PSI in the COOK group and 88.9 PSI in the TERUMO group, the difference was statistically significant (P<0.05). Conclusion: Appropriate pressure should be chosen according to different angiocatheters in the selection of angiographic parameters. Lower pressure is advised in the case of TERUMO MEDICAL RH angiocatheter for good image quality.