Abstract: Objective: To investigate the CT and MRI imaging manifestation of solid-pseudopapillary tumor of pancreas (SPTP) and to improve the diagnostic accuracy of the lesion. Methods: A retrospective analysis was performed on the comprehensive manifestations of CT, MRI and clinical information of 18 cases of SPTP confirmed by pathology and surgery. Results: 13 cases were examined with CT, 8 cases were examined with MRI and 4 cases were examined with both CT and MRI. The patients included 3 male and 15 females with mean age of 33 years (range 17~63). The mean diameter of tumor was 6.0cm. The lesions were located in the pancreatic head in 5 cases, in the pancreatic tail in 13 cases. The tumors had regular shape in 13 cases, irregular shape in 5 cases. 15 cases of plain and enhanced CT scan showed cystic-solid tumors, the solid part of SPTP was mildly enhanced during arterial phase, and it was progressively filled during portal venous phase and equilibrium phase. The cystic part was not enhanced. The capsule of 5 cases was incomplete. 5 cases presented as granular calcification. 8 cases were examined by plain and enhanced MRI and presented cystic-solid tumors. 4 cases appeared hemorrhage with incomplete capsule in 3 cases. 1 case located in the pancreatic head leading to the secondary ducts dilatations. Conclusion: There are some characteristics in the CT and MRI manifestations of SPTP and the comprehensives analysis of imaging manifestations of the lesion has very important valuable for accurate diagnosis and differential diagnosis.