Analysis of Correlation between CT Features of Phase III Pneumoconiosis and Silica Content in the Lungs
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摘要: 目的：应用双源CT双能量扫描技术测量叁期尘肺患者肺组织内二氧化硅（SiO2）含量及混合能量CT值，探讨SiO2含量与其沉积部位及叁期尘肺主要CT表现的关系。结果：①尘肺组肺组织内SiO2含量为（0.57±0.49）mg/mL，健康对照组为（0.26±0.20）mg/mL；尘肺组混合能量CT值为（-777.72±111.33）HU，健康对照组为（-829.95±112.31）HU。尘肺组SiO2含量和混合能量CT值均高于健康对照组，组间差异均有统计学意义（P=0.00）。②比较尘肺组患者肺组织不同沉积部位间SiO2含量和混合能量CT值，发现气管分叉下3cm层面SiO2含量和混合能量CT值均最高，气管分叉下缘层面次之，主动脉弓上缘层面最低，提示叁期尘肺患者肺组织内SiO2主要分布在两下肺野，由下而上其SiO2含量逐渐减低。③比较尘肺组CT影像表现的复杂程度与SiO2含量和混合能量CT值关系，含有5种CT征象者SiO2含量及混合能量CT值最高，均值分别为（0.72±0.58）mg/mL及（-719.30±154.68）HU；仅含1种CT征象者SiO2含量及混合能量CT值最低，均值分别为（0.49±0.40）mg/mL及（-809.74±105.60）HU。提示叁期尘肺患者CT表现越复杂，其肺组织SiO2含量及混合能量CT值越高。结论：双源CT双能量扫描技术可以量化叁期尘肺患者肺组织内SiO2含量及混合能量CT值，其混合能量CT值与SiO2含量有关，SiO2含量与其沉积部位的CT影像表现有关。Abstract: Objective: By using Siemens dual-source CT dual-energy scanning technique, To measure the content of silicon dioxide (SiO2) and the mixed-energy CT value in the tissues of phase III Pneumoconiosis patients, and to find the relationship between the content of SiO2, the main CT features and its deposition site. Results: The content of SiO2 in lung tissue of Pneumoconiosis group was (0.57±0.49) mg/mL, the healthy control group was (0.26±0.20) mg/mL, the mixed energy CT in Pneumoconiosis group was (-777.72±111.33) HU, the healthy control group was (-829.95±112.31) HU. The content of SiO2 and CT value of mixed energy in Pneumoconiosis group were higher than those in healthy control group. There were significant differences between the two groups (P=0.00).Comparing the SiO2 content and the mixed energy CT values between different deposition sites in the Pneumoconiosis group, the highest level was the lower 3cm level of tracheal bifurcation group, the lower edge of tracheal bifurcation group was in the middle, the lowest one was the distal of the aortic arch level group. The results showed that there was significant difference between the three levels. The SiO2 was mainly distributed in two lower lung fields in patients with Pneumoconiosis phase III, and it was decreased gradually from the base to the top. Comparing the relationship between the complexity of the CT features and the content of SiO2 as well as the mixed energy CT values, the content of SiO2 and the mixed energy CT values were the highest in people have five CT manifestations group, with the mean values of (0.72±0.58) mg/mL and (-719.30±154.68) HU. The lowest was found in people only have one CT manifestations group, with the mean values of (0.49±0.40) mg/mL and (-809.74±105.60) HU. The result was that the more complex of the CT features in Pneumoconiosis phase III patients, the higher the SiO2 content and the mixed energy CT value inside. Conclusion: Dual-source CT dual-energy scanning can quantitatively evaluate the amount of SiO2 and the mixed energy CT value in the lung tissue. The content of SiO2 is positively correlated with mixed energy CT value; moreover the content and CT value are related to the location of silica deposition and the main CT manifestations.
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Keywords:
- dual source CT /
- dual energy scanning technology /
- SiO2 /
- mixed energy CT value
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期刊类型引用(5)
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