Abstract: Objective: To evaluate the clinical and radiological factors associated with rapid growth of pGGN patients during the follow-up period of 3 years, and to provide evidence for clinical individualized management. Materials and Methods: A retrospective analysis of 93 patients with pGGN who were followed up for 3 years and above by HRCT at Zhongshan Hospital affiliated to Dalian University. A total of 138 pGGN lesions were divided into growth group and stable group to analyze the influencing factors between clinical information and HRCT signs and growth of pGGN within 3 years. Results: Of the 138 pGGN lesions, 25 increased during the 3-year follow-up period, and 113 pGGN remained stable during the 3-year follow-up period. For human-based analysis, the growth frequency of pGGN was 23.6% (22/93) within 3 years of follow-up. Based on the analysis of the nodules, the growth frequency was 18.1% (25/138). In the multivariate analysis, the initial diameter was>8.5mm (OR=53.774, 95% CI: 9.658 to 299.389, P=0.000), pGGN was irregularly shaped (OR=12.828, 95% CI: 1.559 to 105.547, P=0.018) are independent risk factors for pGGN growth within 3 years. Conclusions: For pGGN patients with the above imaging signs, Positive surgical intervention may be a more appropriate clinical management approach than continued follow-up observation.