Explore the Risk Factors for the Growth of Pure Lung Ground Glass Nodules During the 3-year Follow Up Period
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摘要: 目的：评估与pGGN患者在3年随访期内增长相关的临床和放射学因素，为临床个体化管理提供依据。资料与方法：回顾性分析HRCT随访3年及以上pGGN患者93位，共138例pGGN病灶，并分为增长组及稳定组，分析患者临床资料和HRCT征象与pGGN 3年随访期内出现增长间的关系。结果：138例pGGN病灶中，25例在3年随访期间出现增长，113例pGGN在3年随访期间保持稳定。对以人为基础的分析，随访3年内出现增长的pGGN的比例为23.6％（22/93）；而基于对结节的分析中，增长的比例为18.1％（25/138）。在多变量分析中，初始直径大于8.5mm（OR=53.774，95％，CI：9.658～299.389，P=0.000），pGGN形状为不规则形（OR=12.828，95％，CI：1.559～105.547，P=0.018）是pGGN 3年内发生增长的独立危险因素。结论：当pGGN患者病灶最大径大于8.5mm，形状呈不规则形时，相比于继续随访观察，积极的外科干预可能是更合适的临床管理方式。Abstract: Objective: To evaluate the clinical and radiological factors associated with rapid growth of pGGN patients during the follow-up period of 3 years, and to provide evidence for clinical individualized management. Materials and Methods: A retrospective analysis of 93 patients with pGGN who were followed up for 3 years and above by HRCT at Zhongshan Hospital affiliated to Dalian University. A total of 138 pGGN lesions were divided into growth group and stable group to analyze the influencing factors between clinical information and HRCT signs and growth of pGGN within 3 years. Results: Of the 138 pGGN lesions, 25 increased during the 3-year follow-up period, and 113 pGGN remained stable during the 3-year follow-up period. For human-based analysis, the growth frequency of pGGN was 23.6% (22/93) within 3 years of follow-up. Based on the analysis of the nodules, the growth frequency was 18.1% (25/138). In the multivariate analysis, the initial diameter was>8.5mm (OR=53.774, 95% CI: 9.658 to 299.389, P=0.000), pGGN was irregularly shaped (OR=12.828, 95% CI: 1.559 to 105.547, P=0.018) are independent risk factors for pGGN growth within 3 years. Conclusions: For pGGN patients with the above imaging signs, Positive surgical intervention may be a more appropriate clinical management approach than continued follow-up observation.
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Keywords:
- chest computed tomography /
- pure ground glass nodule /
- follow-up /
- growth
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