Abstract: Objective:To discuss the CT and clinical characteristics of COVID-19 patients with multiple ground glass shadows (GGO), in order to improve the understanding of this disease. Methods:Clinical and CT imaging data of 12 COVID-19 patients were retrospectively analyzed, at the same time, the signs of the CT images and the corresponding pathological basis were analyzed. Results:Among the 12 COVID-19 patients with multiple GGO, there were 11 cases of fever,11 cases of cough, 2 cases with the number of lesions ≤ 5, 2 cases with the number of lesions ranging from 6 to 10, and 8 cases with the number of lesions >8; there were 10 cases involving the upper lobe, 10 cases involving the middle and tongue lobe, 11 cases involving the lower lobe, and 9 cases involving the upper, middle (tongue) and lower lobes; there were septal thickening in 11 cases; lesions with consolidation in 7 cases; pleural changes were observed in 11 cases, among which pleural thickening was observed in 10 cases and a small amount of effusion was observed in 1 case. No mediastinal or hilar lymph node enlargement was observed in all patients. Conclusion:It has some certain characteristics on CT and clinical manifestations of covid-19 patients with multiple ground glass shadows (GGO). Combining with epidemiology and laboratory examination findings can help make the diagnosis and differential diagnosis.