Abstract: Objective:The purpose of this study was to discuss the effect of high iodine concentration contrast media in patients with Crohn's disease, by comparing the degree of the image quality of abdominal artery and enhancement of thicken bowel wall by using non-ionic contrast agent of different iodine concentrations. Methods:This study was retrospectively performed in 30 patients with known Crohn's disease from May 2016 to January 2019 who underwent CTE. They were assigned into two groups according to different iodine concentration injection, high-concentration iodinated contrast medium(Group A, 400 mgI/mL) and regular-concentration iodinated contrast medium(Group B, 350 mgI/mL). The bolus tracking technique was used to initiate the arterial phase scan. The degrees of image quality were rated on a 3-point scale for qualitative assessment. The computed tomography values of abdominal aorta and Superior mesenteric artery and intestinal wall enhancement were measured for quantitative evaluation, and CNR was computed. The independent t-test was used to compare outcome variables. Results:Group A had significantly higher scores for vascular enhancement image quality(P < 0.05). The mean Abdominal aorta and Superior mesenteric artery enhancement was significantly higher in group A than in group B during the arterial phases(P=0.025). Relative enhancement value of intestinal wall in arterial phase was(39.25 ±11.99) HU and(30.27 ±11.69) HU, respectively, which group A was high than that of group B. The difference was statistically significant(P < 0.05). The CNR of abdominal vascular overall in group A is higher than group B(P < 0.05). Conclusion:Our study suggests that, in patient with Crohn's disease, an increased concentration of iodine improves the image quality of abdominal vascular and its branches, and contributes to a better enhancement in intestinal wall.