Abstract: Objective:To investigate the diagnostic value of CTA and DSA in spontaneous isolated mesenteric artery dissection. Methods:The clinical data of 21 patients admitted to our hospital from January 2017 to December 2019 were retrospectively analyzed, and CTA and DSA were performed in all selected patients. Calculate the sensitivity, specificity, positive predictive value, negative predictive value and accuracy of CTA to SISMAD. To compare whether there are statistically significant differences in the accuracy of the two in the diagnosis of sismad. Using DSA as the gold standard, CTA performed a consistent Kappa test on the inspection results of SISMAD. Results:Of the 21 patients, 20 were diagnosed by CTA as SISMAD, one was superior mesenteric artery embolization, and the accuracy of CTA in the diagnosis of SISMAD was 95.23%. There was no significant difference in the accuracy of the two diagnoses(P>0.05). The sensitivity, specificity, positive predictive value and negative predictive value to type Ⅰ SISMAD were 75%, 84.61%, 75% and 84.61% respectively. The sensitivity, specificity, positive predictive value and negative predictive value of type Ⅱa SISMAD were 60%, 87.5%, 60%, 87.5%; The sensitivity, specificity, positive predictive value and negative predictive value of type Ⅱb SISMAD were 71.43%, 85.71%, 71.43%, 85.71%, 85.71%, respectively. The results of CTA examination of SISMAD were consistent with those of DSA(Kappa=0.738). Conclusion:CTA can diagnose spontaneous solitary mesenteric artery dissection quickly and accurately, and it has important guidance for the next treatment significance, which is worthy of clinical promotion and use.