ISSN 1004-4140
CN 11-3017/P

基于BSA及固定碘速率探讨不同浓度对比剂对肝静脉CT成像效果的影响

董相宇, 方挺松, 袁健祥, 梁振华, 李均洪

董相宇, 方挺松, 袁健祥, 梁振华, 李均洪. 基于BSA及固定碘速率探讨不同浓度对比剂对肝静脉CT成像效果的影响[J]. CT理论与应用研究, 2021, 30(4): 466-476. DOI: 10.15953/j.1004-4140.2021.30.04.07
引用本文: 董相宇, 方挺松, 袁健祥, 梁振华, 李均洪. 基于BSA及固定碘速率探讨不同浓度对比剂对肝静脉CT成像效果的影响[J]. CT理论与应用研究, 2021, 30(4): 466-476. DOI: 10.15953/j.1004-4140.2021.30.04.07
DONG Xiangyu, FANG Tingsong, YUAN Jianxiang, LIANG Zhenhua, LI Junhong. Discussion on the Effect of Different Concentrations of Contrast Media on CT Imaging of Hepatic Veins Based on BSA and Fixed Iodine Rate[J]. CT Theory and Applications, 2021, 30(4): 466-476. DOI: 10.15953/j.1004-4140.2021.30.04.07
Citation: DONG Xiangyu, FANG Tingsong, YUAN Jianxiang, LIANG Zhenhua, LI Junhong. Discussion on the Effect of Different Concentrations of Contrast Media on CT Imaging of Hepatic Veins Based on BSA and Fixed Iodine Rate[J]. CT Theory and Applications, 2021, 30(4): 466-476. DOI: 10.15953/j.1004-4140.2021.30.04.07

基于BSA及固定碘速率探讨不同浓度对比剂对肝静脉CT成像效果的影响

基金项目: 

佛山市十三五重点专科项目(FSZDZK135017);佛山市重点专科培育项目(Fspy3-2015019)。

详细信息
    作者简介:

    董相宇*,男,大学本科,广州中医药大学附属佛山中医院医学影像科副主任技师,主要从事CT诊疗及数字化图像处理工作,E-mail:dxy521622@163.com。

  • 中图分类号: R814

Discussion on the Effect of Different Concentrations of Contrast Media on CT Imaging of Hepatic Veins Based on BSA and Fixed Iodine Rate

  • 摘要: 目的:探讨基于体表面积(BSA)和固定碘速率给药,不同浓度对比剂对CT肝静脉成像质量的影响。方法:选取2020年1月至11月符合纳入标准,行上腹部增强CT扫描的患者130例,根据所用对比剂浓度不同,分为高浓度组(62例)和低浓度组(68例),高浓度组对比剂为碘帕醇(含碘370mg/mL),低浓度组对比剂为碘佛醇(含碘320mg/mL);根据BSA计算患者所用对比剂的总量,固定碘速率注射,进行分期动态扫描。选取肝静脉期数据行肝静脉血管重建,对图像质量进行评价,测量两组图像肝静脉和肝实质的CT值及其标准差值,计算信噪比和对比噪声比,并对图像质量进行主观评分;采用独立样本t检验比较两组间客观评价指标的差异,采用Mann-Whitney U检验比较主观评分的差异。结果:高、低浓度组图像评分分别为(3.74±0.47)分和(3.77±0.53)分,差异无统计学意义;两组间肝静脉左、中、右三支主干和同层面肝实质的CT值、SD值、SNR及肝静脉相对于肝实质的CNR,差异无统计学意义。结论:基于BSA及固定碘速率注射对比剂,两种不同浓度对比剂在肝静脉CT成像中的效果同样清晰利于诊断。
    Abstract: Objective: To explore the effects of different concentrations of contrast agents on the quality of CT hepatic venous imaging based on body surface area (BSA) and fixed iodine rate administration. Method: According to the inclusion criteria, 130 patients were selected and received enhanced upper abdominal CT scan from January to November 2020. According to the different contrast agents, they were divided into high concentration group (62 cases) and low concentration group (68 cases). The contrast agent of the high concentration group was iopamidol (containing iodine 370mg/mL), and the contrast agent of the low concentration group was ioversol (containing iodine 320mg/mL). To calculate the total amount of iodine based on BSA. fixed iodine rate administration, and triple-phase enhanced CT scans. Hepatic vein phase data were selected for reconstruction of hepatic vein vessels, and image quality was evaluated. CT values and standard deviations of hepatic vein and liver parenchyma of the two groups of images were measured. Signal-to-noise ratio (SNR) and contrastive noise ratio (CNR) were calculated, and image quality was evaluated subjectively. The independent sample t test was used to compare the differences in objective evaluation indicators between the two groups, and the Mann-Whitney U test was used to compare the differences in subjective scores. Results: The image scores of high and low concentration groups were (3.74±0.47) points and (3.77±0.53) points, respectively, with no statistical significance; There were no significant differences in CT values, SD values, SNR values of the left, middle and right branches of hepatic vein and liver parenchyma at the same level between the two groups. Conclusion: Based on BSA and fixed iodine rate injection contrast agent, the effect of two different concentrations of contrast agent in hepatic venous CT imaging is equally clear and conducive to diagnosis.
  • [1] 罗昆, 董仟, 杨明, 等. 双低对比剂联合能谱CT成像技术在门静脉成像中的应用研究[J]. 临床放射学杂志, 2016, 35(11):1759-1763.

    LUO K, DONG Q, YANG M, et al. The clinical research of "double low" contrast medium combined with spectral CT imaging in CT portal venography[J]. Journal of Clinical Radiology, 2016, 35(11):1759-1763. (in Chinese).

    [2] 殷小平, 王佳宁, 田笑, 等. 能谱CT最佳单能量成像优化肝脏血管图像质量的研究[J]. 放射学实践, 2017, 32(9):942-946.

    YIN X P, WANG J N, TIAN X, et al. Study of optimal monochromatic mode with spect ral CT imaging for the improvement of image quality of liver vessels[J]. Radiologic Practice, 2017, 32(9):942-946. (in Chinese).

    [3] 王威, 赵振, 秦智, 等. 不同浓度对比剂对门静脉CT成像效果的对比研究[J]. 中华放射学杂志, 2020, 54(5):413-416.

    WANG W, ZHAO Z, QIN Z, et al. Comparison of different contrast agent concentrations in CT portal venography[J]. Chinese Journal of Radiology, 2020, 54(5):413-416. (in Chinese).

    [4] 胡咏梅, 武晓洛, 胡志红, 等. 关于中国人体表面积公式的研究[J]. 生理学报, 1999, 5(1):45-48.

    HU Y M, WU X L, HU Z H, et al. Study of formula for calculating body surface areas of the chinese adults[J]. Acta Physiologica Sinica, 1999, 5(1):45-48. (in Chinese).

    [5]

    ONISHI H, MURAKAMI T, KIM T, et al. Abdominal multi-detector row CT:Effectiveness of determining contrast medium dose on basis of body surface area[J]. European Journal of Radiology, 2011, 80(3):643-647.

    [6]

    KONDO H, KANEMATSU M, GOSHIMA S, et al. Body size indices to determine iodine mass with contrast-enhanced multi-detector computed tomography of the upper abdomen:Does body surface area outperform total body weight or lean body weight?[J].European Radiology, 2013, 23(7):1855-1861.

    [7]

    PAPARO F, GARELLO I, BACIGALUPO L, et al. CT of the abdomen:Degree and quality of enhancement obtained with two concentrations of the same iodinated contrast medium with fixed iodine delivery rate and total iodine load[J]. European Journal of Radiology, 2014, 83(11):1995-2000.

    [8]

    ZHAO L Q, HE W, LI JY, et al. Improving image quality in portal venography with spectral CT imaging[J]. European Journal of Radiology, 2012, 81(8):1677-1681.

    [9]

    BEHRENDT F F, SCHMIDT B, PLUMHANS C, et al. Image fusion in dual energy computed tomography:Effect on contrast enhancement, signal-to-noise ratio and image quality in computed tomography angiography[J]. Investigative Radiology, 2009, 44(1):1-6.

    [10] 徐健, 何小龙, 方焕新, 等. CT冠状动脉成像体型特异性剂量估算值的对比研究[J]. 中华放射医学防护杂志, 2019, 39(7):532-528.

    XU J, HE X L, FANG H X, et al. Comparative analysis of size-specific dose estimates in coronary computed tomography angiography[J]. Chinese Journal of Radiological Medicine and Protection, 2019, 39(7):532-528. (in Chinese).

    [11] 胡茂清, 龙昉, 龙晚生, 等. 基于全体质量、去脂肪体质量和体表面积计算肝脏CT增强碘对比剂用量的对比研究[J]. 实用放射学杂志, 2019, 35(11):1831-1835.

    HU M Q, LONG F, LONG W S, et al. Comparative study among total body weight, lean body weight and body surface area adjusted iodine contrast agent dose protocols on liver enhanced CT scans[J]. Journal of Practical Radiology, 2019, 35(11):1831-1835. (in Chinese).

    [12]

    MARTENS B, HENDRIKS B M F, EIJSVOOGEL N G, et al. Individually body weight-adapted contrast media application in computed tomography imaging of the liver at 90kVp[J]. Investigative Radiology, 2019, 54(3):177-182.

    [13]

    KIDOH M, NAKAURA T, ODA S, et al. Contrast enhancement during hepatic computed tomography:Effect of total body weight, height, body mass index, blood volume, lean body weight, and body surface area[J]. Journal of Computer Assisted Tomography, 2013, 37(2):159-164.

    [14]

    HOSSAIN M A, COSTANZO E, COSENTINO J, et al. Contrastinduced nephropathy:Pathophysiology, risk factors, and prevention[J].Saudi Journal of Kidney Diseases and Transplantation, 2018, 29(1):1-9.

    [15] 夏振营, 丁金立, 尹悦, 等. BSA指导下不同浓度碘对比剂在肝动脉增强效能中的对比研究[J]. CT理论与应用研究, 2019, 28(3):291-298.

    DOI:10.15953/j.1004-4140.2019.28.03.02. XIA Z Y, DING J L, YIN Y, et al. Effect of different concentrations of iodine contrast agent on MSCT hepatic artery enhancement under the guidance of body surface area[J]. CT Theory and Applications, 2019, 28(3):291-298. DOI:10.15953/j.1004-4140.2019.28.03.02. (in Chinese).

    [16] 杨克柽, 李莲, 王建杰, 等. 肝脏CT门静脉成像中对比剂剂量的估算方法[J]. 临床放射学杂志, 2016, 35(4):630-633.

    YANG K J, LI L, WANG J J, et al. Determination of contrast medium dose for CT portal venography:Body weight, body surface area or body mass index[J]. Journal of Clinical Radiology, 2016, 3(4):630-633. (in Chinese).

    [17] 杨琴, 何其舟, 余飞, 等. 基于体表面积和体重的个体化对比剂方案在冠脉CT血管造影中的应用价值[J]. 解放军医学杂志2018, 43(2):135-139.

    YANG Q, HE Q Z, YU F, et al. The value of individualized contrast agent injection regimen in coronary CTA imaging based on body surface area and body weight[J]. Medical Journal of Chinese People's Liberation Army, 2018, 43(2):135-139. (in Chinese).

    [18] 于易通, 尹卫华, 马伟, 等. 冠状动脉CTA个体化对比剂注射方案实现图像质量均一化的可行性研究[J]. 放射学实践, 2019, 34(4):427-431.

    YU Y T, YIN W H, MA W, et al. Feasibility study of individualized contrast medium injection protocol to achieve consistent image quality incoronary CT angiography[J]. Radiologic Practice, 2019, 34(4):427-431. (in Chinese).

    [19] 任占丽, 胡智军, 李豆, 等. 不同比例多模型迭代重建对"三低"CT门静脉成像图像质量的影响[J]. 中国医学影像技术, 2018, 34(10):1568-1573.

    REN Z L, HU Z J, LI D, et al. Impact of different proportions of adaptive statistical iterative reconstruction veo on image quality of "three-low" CT portal venography[J]. Chinese Journal of Medical Imaging Technology, 2018, 34(10):1568-1573. (in Chinese).

    [20] 张龙敏, 刘爱连, 刘义军, 等. 低浓度对比剂能谱CT单能量成像对提高门静脉图像质量的研究[J]. 放射学实践, 2015, 30(4):360-363.

    ZHANG L M, LIU A L, LIU Y J, et al. Study on the effect monochromatic images with best contrast -to-noise ratio using spectral CT for improving the imaging quality of portography using low-concentration contrast medium[J]. Radiologic Practice, 2015, 30(4):360-363. (in Chinese).

    [21] 佟梓滨, 刘爱连, 刘义军, 等. 低浓度对比剂单能量成像对提高肝静脉成像质量的研究[J]. 中国临床医学影像杂志, 2015, 26(2):95-104.

    TONG Z B, LIU A L, LIU Y J, et al. Selecting optimal monochromatic level of spectral CT imaging with low concentration contrast media for improving imaging quality of hepatic veins[J]. Journal of China Clinic Medical Imaging, 2015, 26(2):95-104. (in Chinese).

    [22]

    VERBURG F A, APITZSCH J, LENSING C, et al. Body surface area adapted iopromide 300mg/mL versus 370mg/mL contrast medium injection protocol:Influence on quantitative and clinical assessment in combined PET/CT[J]. European Journal of Radiology, 2013, 82(12):2348-2352.

    [23]

    FREUND M, WESNER F, REIBE F, et al. Spiral CT angiography for preoperative planning in patients with epigastria tumors:Comparison with arteriography[J]. Journal of Computer Assisted Tomography, 1996, 20(4):786-791.

    [24] 姜滨, 张龙江, 沈文, 等. 多层螺旋CT血管成像在肝静脉解剖中的应用研究[J]. 临床放射学杂志, 2006, 26(7):683-687.

    JIANG B, ZHANG L J, SHEN W, et al. The application of multislice CT angiography in hepatic veins anatomy[J]. Journal of Clinical Radiology, 2006, 26(7):683-687. (in Chinese).

    [25] 项劲驰, 罗天友, 熊光明. 时间期相在多层螺旋CT肝脏增强扫描中的特殊应用价值[J]. 重庆医科大学学报, 2008, 33(10):1251-1253.

    XIANG J C, LUO T Y, XIONG G M, et al. The special values of the time phases in liver enhancement scanning with multi-slices helical CT[J]. Journal of Chongqing Medical University, 2008, 33(10):1251-1253. (in Chinese).

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出版历程
  • 收稿日期:  2021-01-03
  • 网络出版日期:  2021-09-23

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