Abstract: Objective: To investigate the diagnostic value of multi-slice spiral CT (MSCT) in extrapancreatic nerve infiltration of pancreatic cancer. Methods: We compared the morphology, size and CT value of celiac ganglia between 20 patients with pancreatic carcinoma and 50 healthy people. Taking the pathological results as the standard, we analyzed the sensitivity, specificity, accuracy of MSCT in diagnosing the celiac ganglia invasion. Results: In the pancreatic cancer group, the shape of abdominal ganglion was coarse strip, and the fat gap between the tumor and the abdominal ganglion was unclear. The shape of abdominal ganglion in healthy control group was fine strip or small nodular, and the surrounding fat gap was clear. The long diameter and short diameter of bilateral abdominal ganglions in the pancreatic cancer group were higher than those in the healthy group, while the three-phase CT values of left abdominal ganglion in the pancreatic cancer group were higher than those in the healthy group. Compared with the pathological results, the sensitivity, specificity and accuracy of CT in the diagnosis of abdominal ganglion invasion in pancreatic cancer were 80%, 60% and 75%, respectively. Conclusion: MSCT holds high diagnostic value for extrapancreatic nerve infiltration, which can clearly show the morphology, size and CT value of abdominal ganglion. The circumstances of thick-strip enlargement of abdominal ganglion, unclear fat gap and occurrence of obvious enhancement indicate the nerve invasion of the existing tumor.