Abstract: Objective: To discuss the application value of CT in the prognostic analysis of ureteral carcinoma. Methods: The CT and medical records of 101 patients with ureteral carcinoma who underwent radical nephroureterectomy from January 2014 to December 2016 were collected and analyzed, and then the Cox regression method was performed. Results: Cox uni-variate analysis revealled that the single risk factors affecting the survival rate of patients with ureteral cancer in CT signs included multiple lesions, necrotic cystic change, maximum diameter ≥3 cm, peritumoral fat infiltration and depth of infiltration, invasion of adjacent organs and tissues, and lymph node metastasis. Cox multi-variate analysis,revealled that the multiple risk factors affecting the long-term survival rate of patients with ureteral cancer in CT signs included peritumoral fat infiltration and depth of infiltration, invasion of adjacent organs and tissues, lymph node metastasis, tumor necrosis and cyst, and multiple lesions. Conclusion: In CT signs, peritumoral fat infiltration and depth of infiltration, invasion of adjacent organs and tissues, lymph node metastasis, tumor necrosis and cystic degeneration and multiple lesions are the main risk factors affecting the survival of patients with ureteral cancer. CT holds great application value in the prognostic analysis of primary ureteral cancer.