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CT动脉增强分数与肝癌TACE治疗效果的相关性研究

龚娜 朱冰洁 余佩君 赵琳 史柯 李辉安

龚娜, 朱冰洁, 余佩君, 等. CT动脉增强分数与肝癌TACE治疗效果的相关性研究[J]. CT理论与应用研究, 2022, 32(0): 1-7. DOI: 10.15953/j.ctta.2021.022
引用本文: 龚娜, 朱冰洁, 余佩君, 等. CT动脉增强分数与肝癌TACE治疗效果的相关性研究[J]. CT理论与应用研究, 2022, 32(0): 1-7. DOI: 10.15953/j.ctta.2021.022
GONG N, ZHU B J, YU P J, et al. Correlation between CT arterial enhancement fraction and TACE efficacy of hepatocellular carcinoma[J]. CT Theory and Applications, 2022, 32(0): 1-7. DOI: 10.15953/j.ctta.2021.022. (in Chinese)
Citation: GONG N, ZHU B J, YU P J, et al. Correlation between CT arterial enhancement fraction and TACE efficacy of hepatocellular carcinoma[J]. CT Theory and Applications, 2022, 32(0): 1-7. DOI: 10.15953/j.ctta.2021.022. (in Chinese)

CT动脉增强分数与肝癌TACE治疗效果的相关性研究

doi: 10.15953/j.ctta.2021.022
基金项目: 安康市科技项目(CT动脉增强分数对肝癌TACE术后疗效的评估(AK2019SF-05))。
详细信息
    作者简介:

    龚娜:女,安康市人民医院副主任医师,研究方向为腹部、盆腔及胎儿诊断,E-mail:gongnaqimei@163.com

    李辉安:男,安康市人民医院主任医师,研究方向为胸腹部影像诊断,E-mail:huian0429@163.com

    通讯作者:

    李辉安*,男,安康市人民医院主任医师,研究方向为胸腹部影像诊断,E-mail:huian0429@163.com

  • 中图分类号: R  814

Correlation between CT Arterial Enhancement Fraction and TACE Efficacy of Hepatocellular Carcinoma

  • 摘要: 目的:探讨CT动脉增强分数(AEF)与肝癌经导管动脉化疗栓塞(TACE)治疗效果的相关性。方法:对我院2019年1月至2020年1月43例原发性肝细胞癌(HCC)患者临床资料进行回顾性分析,所有患者均接受TACE治疗,术前及术后1个月均行CT动态增强扫描检查,根据治疗效果分为治疗有效组及无效组,采用电化学发光法检测各组甲胎蛋白(AFP)水平,比较两组治疗前后AEF、AFP、肿瘤大小变化;采用Pearson系数探究AEF、AFP与肿瘤大小变化的相关性,采用受试者工作特征曲线(ROC)及曲线下面积(AUC)分析肝脏动态增强扫描联合AEF彩图对TACE疗效的评估价值。结果:有效组治疗后AEF、AFP、肿瘤大小均小于治疗前、无效组;Pearson相关性分析结果显示,TACE治疗后AEF、AFP均与肿瘤大小呈正相关;ROC曲线分析结果显示,肝脏动态增强扫描联合AEF评估TACE疗效的AUC为0.902,明显高于肝脏动态增强扫描、AEF单独评估的0.793、0.771。结论:AEF对TACE治疗效果具有良好的评估价值,联合肝脏动态增强扫描能进一步提高准确度,可作为TACE治疗HCC疗效评估的辅助手段,值得临床推广。

     

  • 图  1  肝脏动态增强扫描联合AEF评估TACE疗效的ROC曲线

    Figure  1.  ROC curve of dynamic enhanced liver scanning combined with AEF to evaluate the efficacy of TACE

    图  2  HCC患者AEF伪彩图,CT增强扫描动脉期、门脉期及CT平扫图像

    Figure  2.  AEF and CT image of arterial phase, portal vein phase and PLAIN CT of HCC patients

    表  1  两组治疗AEF、AFP、肿瘤大小比较($ \bar x \pm s $

    Table  1.   Comparison of AEF, AFP and tumor size between the two groups ($ \bar x \pm s $)

    组别AEFAFP/(ng/L)肿瘤大小/cm
    治疗前治疗后治疗前治疗后治疗前治疗后
    有效组0.51±0.130.34±0.05*385.12±10.2984.89±8.39*6.28±1.053.01±0.41*
    无效组0.52±0.090.48±0.07 382.87±21.54373.25±17.82 6.05±1.135.96±1.05
    t0.2657.5940.42072.4360.66713.209
    P0.7920.0000.676 0.0000.509 0.000
     注:与本组治疗前,*-P<0.05。
    下载: 导出CSV

    表  2  AEF、AFP与肿瘤大小的相关性

    Table  2.   Correlation between AEF, AFP and tumor size

    指标肿瘤大小P
    AEF0.5370.002
    AFP0.6490.000
    下载: 导出CSV

    表  3  肝脏动态增强扫描联合AEF对TACE疗效的评估价值

    Table  3.   Evaluation value of dynamic enhanced liver scanning combined with AEF for TACE efficacy

    项目AUCP95% CI
    肝脏动态增强扫描    0.793<0.050.642-0.901
    AEF          0.771<0.050.618-0.885
    肝脏动态增强扫描联合AEF0.902<0.050.773-0.972
    下载: 导出CSV
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  • 收稿日期:  2021-10-19
  • 修回日期:  2022-03-03
  • 录用日期:  2022-03-10
  • 网络出版日期:  2022-07-18

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