ISSN 1004-4140
CN 11-3017/P

CT扫描参数及重建算法对胸部CT值影响的在体研究

李晶晶, 张丽, 刘梦雯, 杨守鑫, 李蒙, 姜九明, 于卫军

李晶晶, 张丽, 刘梦雯, 等. CT扫描参数及重建算法对胸部CT值影响的在体研究[J]. CT理论与应用研究, 2023, 32(4): 480-486. DOI: 10.15953/j.ctta.2022.109.
引用本文: 李晶晶, 张丽, 刘梦雯, 等. CT扫描参数及重建算法对胸部CT值影响的在体研究[J]. CT理论与应用研究, 2023, 32(4): 480-486. DOI: 10.15953/j.ctta.2022.109.
LI J J, ZHANG L, LIU M W, et al. In vivo study of the influence of CT acquisition and reconstruction parameters on chest CT number[J]. CT Theory and Applications, 2023, 32(4): 480-486. DOI: 10.15953/j.ctta.2022.109. (in Chinese).
Citation: LI J J, ZHANG L, LIU M W, et al. In vivo study of the influence of CT acquisition and reconstruction parameters on chest CT number[J]. CT Theory and Applications, 2023, 32(4): 480-486. DOI: 10.15953/j.ctta.2022.109. (in Chinese).

CT扫描参数及重建算法对胸部CT值影响的在体研究

基金项目: 北京市自然科学基金(以像元灰度为基础的影像学特征在早期肺腺癌预后判断中的研究(7184238));国家自然科学基金(基于基线CT放射组学的肺亚实性结节生长模式预测及分子病理基础研究(81701692))
详细信息
    作者简介:

    李晶晶: 女,中国医学科学院肿瘤医院影像诊断科初级技师,主要从事肿瘤放射成像,E-mail:402978478@qq.com

    通讯作者:

    张丽: 女,中国医学科学院肿瘤医院影像诊断科副主任医师、硕士生导师,中华医学会放射学分会心胸学组Youth Club委员,主要从事胸部疾病影像诊断研究,E-mail:zhangli_cicams@163.com

  • 中图分类号: O  242;TP  391

In Vivo Study of the Influence of CT Acquisition and Reconstruction Parameters on Chest CT Number

  • 摘要: 目的:探讨不同扫描参数及重建算法对在体胸部各组织CT值的影响。方法:在不同CT扫描条件下测量人体胸部的气管、血管、肺、椎体与肌肉的CT值。分别设定6组不同扫描参数及重建算法:S1层厚5 mm、50%多模型自适应迭代重建技术(ASIR-V)、低剂量;S2层厚5 mm、滤波反投影(FBP)、常规剂量;S3层厚1.25 mm、50%ASIR-V、低剂量;S4层厚1.25 mm、50% ASIR-V、常规剂量;S5层厚1.25 mm、FBP、低剂量;S6层厚1.25 mm、FBP、常规剂量。扫描的辐射剂量采用两种噪声指数(NI)来进行控制,包括低剂量(NI=40)和常规剂量(NI=10)。采用t检验或秩和检验分析比较不同的两个组之间 CT值的差异。结果:扫描剂量仅对气管CT值的影响具有统计学意义,对其他组织CT值无影响;扫描层厚与重建算法对胸部各个组织CT值的影响均未见统计学差异。结论:人体胸部组织CT值受CT层厚、重建算法和CT剂量的影响小,具有良好的稳定性。
    Abstract: Objective: To explore the influence of different CT acquisition and reconstruction parameters on the CT number of the chest in vivo. Methods: The CT number of the trachea, blood vessels, lungs, vertebral bodies, and muscles of the human chest were measured under different CT scanning parameters. Six groups of different scanning parameters and reconstruction algorithms were set respectively: slice thickness 5 mm, 50% multi-model adaptive statistical iterative reconstruction Veo (ASIR-V) and low-dose for S1; slice thickness 5 mm, filtered back projection (FBP) and standard-dose for S2; slice thickness 1.25 mm, 50% ASIR-V and low-dose for S3; slice thickness 1.25 mm, 50% ASIR-V and standard-dose for S4; slice thickness 1.25 mm, FBP, low-dose for S5; slice thickness 1.25 mm, FBP, standard-dose for S6. The radiation dose of the scan was controlled using two noise indexes (NI), including low-dose (NI=40) and standard-dose (NI=10). Differences in CT number between two groups were compared using t-test or rank-sum test. Results: Significant differences of CT number of the trachea were detected between low-dose and standard-dose, but no significant differences of CT number of other tissues were detected between low-dose and standard-dose. No significant differences of CT number of chest tissues were detected between either 5 mm thickness and 1.25 mm thickness or 50% ASIR-V and FBP. Conclusion: The CT number of human chest tissues showed well stability which was scarcely influenced by slices thickness, reconstruction algorithm and scan dose.
  • 图  1   不同胸部组织在不同序列CT值分布

    ①气管 CT值在1-6序列中的分布,②血管 CT值在1-6序列中的分布,③肺 CT值在1-6序列中的分布,④椎体 CT值在1-6序列中的分布,⑤肌肉 CT值在1-6序列中的分布;通过对CT值两两比较,发现气管CT值在S5与S6两组的差异具有统计学意义,余各组织各序列相互比较均未见显著统计学差异。

    Figure  1.   Distribution of CT number measured in different sequences of each tissue

    表  1   胸部CT扫描参数及重建方法

    Table  1   Chest CT Scanning and reconstruction parameters

    序列号层厚/mm重建算法辐射剂量
    S15.00 50% ASIR-V低剂量 
    S25.00FBP   常规剂量
    S31.25 50% ASIR-V低剂量 
    S41.25 50% ASIR-V常规剂量
    S51.25FBP   低剂量 
    S61.25FBP   常规剂量
    下载: 导出CSV

    表  2   两名研究者测量CT值一致性检验

    Table  2   Interobserver variability test of CT number measured by two doctors

    项目ICC95% CIFP
    S1-气管CT值0.900.83~0.9419.05<0.001
    S2-气管CT值0.750.59~0.856.85<0.001
    S3-气管CT值0.950.91~0.9739.26<0.001
    S4-气管CT值0.930.87~0.9625.72<0.001
    S5-气管CT值0.680.49~0.805.19<0.001
    S6-气管CT值0.640.44~0.784.58<0.001
    S1-血管CT值0.960.93~0.9723.42<0.001
    S2-血管CT值0.850.74~0.926.78<0.001
    S3-血管CT值0.830.71~0.916.03<0.001
    S4-血管CT值0.890.80~0.948.95<0.001
    S5-血管CT值0.850.73~0.916.46<0.001
    S6-血管CT值0.840.71~0.916.14<0.001
    S1-肺CT值 0.730.52~0.843.61<0.001
    S2-肺CT值 0.910.84~0.9511.13<0.001
    S3-肺CT值 0.920.86~0.9612.65<0.001
    S4-肺CT值 0.810.66~0.895.16<0.001
    S5-肺CT值 0.910.84~0.9510.75<0.001
    S6-肺CT值 0.930.88~0.96118.26<0.001
    S1-椎体CT值0.990.96~0.99118.26<0.001
    S2-椎体CT值0.980.97~0.9955.34<0.001
    S3-椎体CT值0.900.83~0.9510.75<0.001
    S4-椎体CT值0.900.81~0.949.26<0.001
    S5-椎体CT值0.930.88~0.9615.17<0.001
    S6-椎体CT值0.880.78~0.938.03<0.001
    S1-肌肉CT值0.840.72~0.916.23<0.001
    S2-肌肉CT值0.870.77~0.937.77<0.001
    S3-肌肉CT值0.750.56~0.863.99<0.001
    S4-肌肉CT值0.880.79~0.938.47<0.001
    S5-肌肉CT值0.800.64~0.884.90<0.001
    S6-肌肉CT值0.880.79~0.938.37<0.001
    下载: 导出CSV

    表  3   各部位不同序列测量CT值的分布情况

    Table  3   Distribution of CT number measured in different sequences of each tissue

    序列气管血管椎体肌肉
    S1-985.15±7.11  45.58±5.00-887.22(-897.64~-865.48)168.44(140.10~215.58)  53.57±5.85
    S2-983.95±7.1141.94(44.98~49.66)-887.48(-902.30~-866.45)166.67(138.18~214.14)53.40(49.62~57.46)
    S3-984.57±7.03  44.84±4.80  -884.84±27.11  177.88±50.97  53.83±6.09
    S4-985.93±6.49  45.58±5.41-893.63(-908.19~-872.49)  178.76±51.34138.60(165.74~221.41)
    S5-981.90±6.81  45.11±4.78  -884.07±28.33162.20(129.89~213.69)  53.58±6.57
    S6-984.89±6.54  45.52±6.01  -884.09±30.24  179.34±52.8654.14(49.78~57.23)
    下载: 导出CSV

    表  4   胸部各组织不同序列CT值比较

    Table  4   Comparison of different sequence CT values of chest tissues

    组织S1 vs S3S2 vs S6S3 vs S4S5 vs S6S3 vs S5S4 vs S6
    z/tPz/tPz/tPz/tPz/tPz/tP
    气管-0.410.680.690.491.000.322.230.03-1.930.06-0.800.43
    血管0.750.46-0.720.47-0.980.33-0.380.70-0.280.780.290.78
    -0.640.52-0.430.66-0.610.540.00>0.99-0.140.89-0.440.66
    椎体0.050.96-0.060.95-0.090.93-0.380.70-0.260.79-0.060.96
    肌肉-0.210.83-0.290.77-0.180.86-0.380.710.190.85-0.110.91
    下载: 导出CSV
  • [1]

    National Lung Screening Trial Research Team, ABERLE D R, ADAMS A M, et al. Reduced lung-cancer mortality with low-dose computed tomographic screening[J]. The New England Journal of Medicine, 2011, 365(5): 395−409. doi: 10.1056/NEJMoa1102873

    [2]

    HANSELL D M, BANKIER A A, MacMAHON H, et al. Fleischner society: Glossary of terms for thoracic imaging[J]. Radiology, 2008, 246(3): 697−722. doi: 10.1148/radiol.2462070712

    [3]

    GODOY M C, NAIDICH D P. Subsolid pulmonary nodules and the spectrum of peripheral adenocarcinomas of the lung: Recommended interim guidelines for assessment and management[J]. Radiology, 2009, 253(3): 606−622. doi: 10.1148/radiol.2533090179

    [4] 李琼, 于红, 张丽, 等. 迭代重建技术对低管电压胸部CT增强扫描图像质量的影响[J]. 实用放射学杂志, 2012,28(10): 1615−1618. doi: 10.3969/j.issn.1002-1671.2012.10.033

    LI Q, YU H, ZHANG L, et al. The effect of iterative reconstruction on image quality of contrast-enhanced chest CT with low tube voltage settings[J]. Journal of Practical, 2012, 28(10): 1615−1618. (in Chinese). doi: 10.3969/j.issn.1002-1671.2012.10.033

    [5] 彭文献, 彭天舟, 夏顺仁, 等. X线管电压对生物组织CT值影响的实验研究[J]. 放射学实践, 2013,28(11): 1102−1104.

    PENG W X, PENG T Z, XIA S R, et a1. The effects of X-ray tube voltage on tissue CT value[J]. Radiologic Practice, 2013, 28(11): 1102−1104. (in Chinese).

    [6] 彭文献, 彭天舟, 叶小琴, 等. CT扫描参数对人体组织CT值影响的研究[J]. 中华放射医学与防护杂志, 2010,30(1): 79−81. doi: 10.3760/cma.j.issn.0254-5098.2010.01.026

    PENG W X, PENG T Z, YE X Q, et al. Effect of CT scanning parameters on CT number[J]. Chinese Journal of Radiological Medicine and Protection, 2010, 30(1): 79−81. (in Chinese). doi: 10.3760/cma.j.issn.0254-5098.2010.01.026

    [7] 赵雷, 刘波. 重建算法及射束硬化伪影对CT值测量的影响[J]. 影像研究与医学应用, 2019,3(14): 88−90.
    [8] 韩萍, 于春水, 余永强, 等. 医学影像诊断学[M]. 4版. 北京: 人民卫生出版社, 2017: 4-5.
    [9] 朱明, 刘贵霞, 李敬玉. CT扫描参数对CT值影响因素的实验研究[J]. 中国中西医结合影像学杂志, 2017,15(4): 91−93. doi: 10.3969/j.issn.1672-0512.2017.04.029
    [10]

    AOKAGE K, MIYOSHI T, ISHII G, et al. Clinical and pathological staging validation in the eighth edition of the TNM classification for lung cancer: Correlation between solid size on thin-section computed tomography and invasive size in pathological findings in the new T classification[J]. Journal of Thoracic Oncology, 2017, 12(9): 1403−1412. doi: 10.1016/j.jtho.2017.06.003

    [11]

    HENSCHKE C I, YIP R, SMITH J P, et al. CT screening for lung cancer: Part-solid nodules in baseline and annual repeat rounds[J]. American Journal of Roentgenology, 2016, 207(6): 1176−1184. doi: 10.2214/AJR.16.16043

    [12]

    YANKELEVITZ D F, YIP R, SMITH J P, et al. CT screening for lung cancer: Nonsolid nodules in baseline and annual repeat rounds[J]. Radiology, 2015, 277(2): 555−64. doi: 10.1148/radiol.2015142554

    [13] 张丽, 吴宁, 李蒙, 等. Ⅰ期浸润性肺腺癌磨玻璃成分定量分析与附壁样生长的相关性研究[J]. 中华肿瘤杂志, 2017,39(4): 269−273. doi: 10.3760/cma.j.issn.0253-3766.2017.04.006

    ZHANG L, WU N, LI M, et al. The correlation study of ground glass opacity and lepidic growth pattern component in stage I lung invasive adenocarcinoma[J]. Chinese Journal of Oncology, 2017, 39(4): 269−273. (in Chinese). doi: 10.3760/cma.j.issn.0253-3766.2017.04.006

    [14]

    GAO C, LI J, WU L, et al. The natural growth of subsolid nodules predicted by quantitative initial CT features: A systematic review[J]. Frontiers in Oncology, 2020: 10318.

    [15] 蒋宇, 贾晓民, 赵杰. 肺亚实性结节CT定量分析对肺腺癌病理侵袭性诊断价值[J]. 放射学实践, 2021,36(10): 1232−1237. doi: 10.13609/j.cnki.1000-0313.2021.10.007

    JIANG Y, JIA X M, ZHAO J. Diagnostic value of quantitative CT analysis of pulmonary subsolid nodules to lung adenocarcinoma[J]. Radiologic Practice, 2021, 36(10): 1232−1237. (in Chinese). doi: 10.13609/j.cnki.1000-0313.2021.10.007

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  • 收稿日期:  2022-09-04
  • 网络出版日期:  2022-09-29
  • 发布日期:  2023-07-30

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