The Value of Spectral CT in Differential Diagnosis and Radiotherapy Localiation of Central Lung Cancer with Obstructive Atelectasis
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摘要: 目的：探讨能谱CT扫描在诊断中央型肺癌合并阻塞性肺不张及放疗前定位鉴别肿瘤边界、精准勾画靶区中的应用价值。方法：回顾性分析我院65例经病理证实的中央型肺癌伴阻塞性肺不张患者的放疗前定位 Ⅲ期能谱CT扫描的影像资料，比较分析Ⅲ期增强CT扫描不同参考指标（BMI、BMI-ICM及Eff-Z、PI）显示瘤-肺交界面评分值差异，比较肿瘤与不张肺组织IC值及CT值差异。结果：Ⅲ期增强CT扫描瘤-肺边界评分4项指标（BMI、BMI-ICM及Eff-Z、PI）间存在统计学差异，BMI-ICM最高，PI最低；动脉期、静脉期及延迟期 Ⅲ期扫描中，显示瘤-肺边界的主观评分有差异，动脉期最高；肿瘤与不张肺组织IC值及CT值差异具有统计学意义，IC值比CT值差别更大。结论：能谱CT扫描的不同指标能帮助鉴别中央型肺癌与不张肺组织的边界，利用最佳指标实现放疗前精准勾画放疗靶区，实现放疗计划最优化。Abstract: Objective: To investigate the value of spectral CT in differential central lung cancer from obstructive atelectasis for achieving the accurate delineation and radiotherapy localiation. Methods: The CT radiotherapy localiation images of three phase contrast enchancement by spectral CT of 65 patients confirmed by pathology with central lung cancer and obstructive atelectasis with were collected and analyzed. The scores and detection rates of tumor-lung interface between the polychromatic image (PI), the best monochromatic image (BMI), the effective atomic number (Eff-Z) and the best monochromatic image combined with iodine concentration map (BMI-ICM) were compared. Results: Statistical differences in the scores of tumor-lung interface were observed between PI, BMI, Eff-Z and BMI-ICM; the pairwise comparison showed that the subjective score of BMI-ICM was the highest, and PI was the lowest. The pulmonaty artery phase detection rates of tumor-lung interface of three phase contrast enchancement were the highest. There was statistical difference of iodine concentration (IC) and CT score between lung cancer and obstructive atelectasis. The difference of IC was higher than the CT score. Conclusion: Spectral CT is helpful to distinguish central lung cancer delineation from atelectasis. It provides a new method to delineate the radiotherapy localiation for radiotherapy plan of optimization.
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Keywords:
- spectral CT /
- lung tumor /
- pulmonary atelectasis /
- radiotherapy
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图 1 左肺上叶中央型肺癌并左肺上叶不张混合能量平扫+增强扫描
Figure 1. The left upper lobe central lung cancer with obsrtuctive atelectasis of polychromatic image flat scan and enhancement
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图 2 左肺上叶中央型肺癌并左肺上叶不张单能量增强扫描及能谱曲线
Figure 2. The Spectral HU curve of the same patient and monochromatic image of 56 keV and 75 keV
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图 3 左肺上叶中央型肺癌并左肺上叶不张最佳单能量56 keV增强扫描碘基图及有效原子序数图
Figure 3. The best monochromatic enhancement image combined with iodine concentration map and effective atomic number image
表 1 增强CT扫描各期PI、BMI及BMI-ICM瘤-肺边界主观评分的比较
Table 1 The scores and detection rates of tumor-lung interface of PI, BMI, BMI-ICM and Eff-Z in three phase contrast enchancement
扫描期相 瘤-肺边界主观评分值 统计检验 PI BMI BMI-ICM Eff-Z F P 动脉期 2.51±0.83 3.14±0.85 3.84±0.31 3.04±0.55 34.28 ＜0.01 静脉期 2.14±0.65 2.95±0.89 3.34±0.25 2.84±0.26 26.54 ＜0.01 延迟期 2.12±0.55 2.54±0.35 3.04±0.85 2.74±0.15 18.32 ＜0.01 
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表 2 增强CT扫描各期肿瘤与不张肺组织碘浓度IC值及CT值的比较
Table 2 The scores of tumor-lung interface of IC and CT scores in three phase contrast enchancement
扫描期相 组织IC/100 μg·mL-1 CT值/HU 统计检验 肿瘤 不张肺组织 肿瘤 不张肺组织 t P 动脉期 12.51±3.89 23.71±8.12 35.41±6.85 50.21±9.76 -4.89 ＜0.01 静脉期 11.41±3.23 18.31±6.37 38.38±4.03 42.37±7.83 -6.43 ＜0.01 延迟期 10.11±3.63 17.96±5.93 18.51±5.84 17.01±7.73 -6.82 ＜0.01
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