佛山市成年居民骨密度CT定量研究

吴伟智; 方挺松; 梁振华; 祝翠玲; 周静仪

doi:10.15953/j.ctta.2023.098

佛山市成年居民骨密度CT定量研究

佛山市中医院放射科, 广东佛山528000

基金项目: 2022年佛山市自筹经费类科技创新项目入库培育项目（2220001004568）；佛山市“十四五”医学重点专科项目（FSZD145011）。

详细信息

通讯作者:
吴伟智: 男，硕士，佛山市中医院放射科副主任医师，主要研究方向为骨关节系统疾病的影像诊断与人工智能影像组学，E-mail：success2@163.com

中图分类号: R 814
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出版历程
- 收稿日期: 2023-04-23
- 修回日期: 2023-07-27
- 录用日期: 2023-07-27
- 网络出版日期: 2023-08-08
- 刊出日期: 2024-02-29

Quantitative Computed Tomography Study of Bone Mineral Density for Adults Residents in Foshan

Department of Radiology, Foshan Hospital of TCM, Foshan 528000, China

摘要

摘要:
目的：研究佛山地区成年人椎体骨密度（BMD）与性别、年龄的关系，探讨本地区不同年龄段BMD均值及各年龄段骨质疏松症（OP）的发病率。方法：对佛山市中医院2021年10月至2023年3月的1065例（男性648例，女性417例）健康成年人体检者使用定量CT（QCT）行椎体BMD检测，按年龄段进行分组；采用t检验和方差分析对不同性别、不同年龄段BMD值进行检验，采用$\chi^2 $检验和相关分析对不同性别、不同年龄段的OP发病率进行分析。结果：20～29岁、30～39岁、40～49岁及60～69岁、70～79岁不同性别间的BMD差异均有统计学意义，女性BMD在青中年时期高于男性。在40～49岁、50～59岁、60～69岁、70～79岁男性组及30～39、40～49岁、50～59岁、60～69岁女性组中，同性别不同年龄段间的BMD值差异有统计学意义，且随年龄的增长呈下降趋势；同性别不同年龄段的OP发病率差异均有统计学意义，年龄与OP发病率呈正相关关系（r_男=0.517，r_女=0.636）。结论：佛山市健康成年人QCT测量的椎体BMD与性别、年龄相关，在20～29岁达到峰值，随年龄的增长而下降；从40～49岁开始，OP发病率在男性和女性中随着年龄的增长而增加。
- 定量CT /
- 骨密度 /
- 骨质疏松症 /
- 相关性
Abstract:
Objective: To study the relation between adult vertebral bone mineral density (BMD) and gender and age in Foshan, to explore the average BMD of each age group and osteoporosis (OP) incidence distribution in the region. Methods: Quantitative computed tomography (QCT) was used to examine and record the vertebral BMD of 1065 (male 648, female 417) healthy adults who underwent physical examination in Foshan Hospital of TCM from October 2021 to March 2023, and grouped according to age, T test and variance analysis were used on BMD in different sex and age group. Chi square analysis and correlation analysis were used on the incidence of OP in different sex and age group. Results: There was significant difference in the BMD between male and female of 20~29, 30~39, 40~49 and 60~69, 70~79 years old, women had higher peak BMD than man in young to middle age. In the male groups of 40~49、50~59, 60~69, 70~79 and female groups of 30~39, 40~49, 50~59, 60~69 years old, there were also significant differences in BMD in different age groups of the same sex, and decreased with age. There was significant difference in the incidence of OP between different age groups in the male and female groups. Age was positively related to the incidence of OP (r=0.517 for male and r=0.636 for female). Conclusion: The vertebral BMD derived from QCT for healthy adults in Foshan are associated with sex and age, peaked at 20~29 years old, and decreased with age. The incidence of OP for male and female increased with age from 40~49 years old.
- quantitative CT (QCT) /
- bone mineral density (BMD) /
- osteoporosis (OP) /
- correlation

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图 1 椎体骨密度QCT测量方法

QCT测量的是椎体中央骨松质的体积骨密度，兴趣区避开骨皮质、骨岛和椎体后静脉区；其测量结果不受身高体重、脊柱侧弯、退变和血管钙化等因素的影响。

Figure 1. Measurement of vertebral bone mineral density by QCT

下载: 全尺寸图片幻灯片

表 1 1065例健康成年人胸部CT体检者椎体BMD分析（$\bar x \pm s $，mg/cm³）

Table 1 Analysis of vertebral BMD in 1065 healthy adults undergoing chest CT examination

年龄组/岁	男性		女性		t	P
年龄组/岁	人数/例	BMD	人数/例	BMD	t	P
20～29	41	163.31±26.28	21	188.38±28.79	-3.442	0.001
30～39	93	160.62±26.86	64	172.42±29.21^b	-2.610	0.010
40～49	168	145.47±29.67^a	97	158.05±32.50^b	-3.211	0.001
50～59	211	127.1±28.72^a	127	127.95±38.05^b	-0.215	0.830
60～69	79	107.54±29.85^a	67	92.36±25.64^b	3.263	0.001
70～79	40	96.11±23.60^a	25	84.43±18.11	2.114	0.038
80～89	16	91.51±26.78	16	77.38±17.21	1.775	0.086
F	56.893		74.37
P	<0.001		<0.001
注：a表示在男性组中，该年龄段与前一年龄段比较P<0.05；b表示在女性组中，该年龄段与前一年龄段比较P<0.05。

下载: 导出CSV

表 2 1065例健康成年人胸部CT体检者骨质疏松筛查结果（例（％））

Table 2 Screening results of osteoporosis in 1065 healthy adults undergoing chest CT examination

年龄组/岁	男性				女性
年龄组/岁	正常	低骨量	OP	严重OP	正常	低骨量	OP	严重OP
20～29	38（92.68）	3（7.32）	0（0.00）	0（0.00）	21（100.00）	0（0.00）	0（0.00）	0（0.00）
30～39	90（96.77）	3（3.23）	0（0.00）	0（0.00）	61（95.31）	3（4.69）	0（0.00）	0（0.00）
40～49	137（81.55）	29（17.26）	1（0.60）	1（0.60）	85（87.63）	11（11.34）	0（0.00）	1（1.03）
50～59	125（59.24）	68（32.23）	13（6.16）	5（2.37）	68（53.54）	41（32.28）	12（9.45）	6（4.72）
60～69	25（31.65）	39（49.37）	13（16.46）	2（2.53）	8（11.94）	35（52.24）	22（32.84）	2（2.99）
70～79	4（10.00）	23（57.50）	11（27.50）	2（5.00）	1（4.00）	11（44.00）	10（40.00）	3（12.00）
80～89	2（12.50）	7（43.75）	4（25.00）	3（18.75）	0（0.00）	4（25.00）	10（62.50）	2（12.50）
$\chi^2 $	225.201				235.748
P	<0.001				<0.001

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期刊类型引用(5)

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2.	李梦雨，段诗苗，张雷，周咏春. 提高肺SBRT精度的多窗位动态组合诊疗手段. 中国CT和MRI杂志. 2024(04): 63-65 . 百度学术
3.	宁先英，胡柳，范文亮，余建明，雷子乔. 双层探测器光谱CT单能量成像在泪道造影中的应用研究. CT理论与应用研究. 2024(06): 677-682 . 本站查看
4.	汤江林，陈明伟，刘鲁根，占志强，罗丰珩，乔浩. 人工智能技术用于肺癌放射治疗靶区勾画中的临床效果研究. 中国医学装备. 2024(11): 7-11 . 百度学术
5.	刘小忠. 多层螺旋CT结合胸部X线检查在中央型肺癌临床诊断中的应用价值分析. 现代诊断与治疗. 2024(21): 3270-3271+3274 . 百度学术