ISSN 1004-4140
CN 11-3017/P
陈辉, 张紫欣, 李晶晶, 等. 合并基础病的老年人新型冠状病毒Omicron变异株感染的胸部CT和临床特征分析[J]. CT理论与应用研究(中英文), xxxx, x(x): 1-9. DOI: 10.15953/j.ctta.2024.037.
引用本文: 陈辉, 张紫欣, 李晶晶, 等. 合并基础病的老年人新型冠状病毒Omicron变异株感染的胸部CT和临床特征分析[J]. CT理论与应用研究(中英文), xxxx, x(x): 1-9. DOI: 10.15953/j.ctta.2024.037.
CHEN H, ZHANG Z X, LI J J, et al. Imaging and Clinical Characteristics of SARS-CoV-2 Omicron Variants in Elderly Patients with Underlying Diseases[J]. CT Theory and Applications, xxxx, x(x): 1-9. DOI: 10.15953/j.ctta.2024.037. (in Chinese).
Citation: CHEN H, ZHANG Z X, LI J J, et al. Imaging and Clinical Characteristics of SARS-CoV-2 Omicron Variants in Elderly Patients with Underlying Diseases[J]. CT Theory and Applications, xxxx, x(x): 1-9. DOI: 10.15953/j.ctta.2024.037. (in Chinese).

合并基础病的老年人新型冠状病毒Omicron变异株感染的胸部CT和临床特征分析

Imaging and Clinical Characteristics of SARS-CoV-2 Omicron Variants in Elderly Patients with Underlying Diseases

  • 摘要: 目的:探讨合并基础病的老年患者感染新型冠状病毒Omicron变异株的胸部CT和临床特征。方法:回顾性收集首都医科大学附属北京地坛医院确诊的140例新型冠状病毒Omicron变异株感染合并基础病的老年患者,根据临床分型分为中型组和重型/危重型组,分析两组患者的临床特征、实验室检查和胸部CT影像特征(肺内病灶分布、病灶形态、CT影像征象及肺叶评分)。结果:合并基础疾病的老年新冠病毒Omicron变异株感染者中高血压/高脂血症的发病率最高,胸部CT表现为磨玻璃密度影为主,分布以多肺叶混合分布为主,临床表现主要为发热、咳嗽/咳痰等。重型/危重型组患者发热比例高于中型组(P=0.032)。中型组的淋巴细胞计数值高于重型/危重型组(P=0.037),而重型/危重型组的降钙素原值高于中型组(P=0.001)。重型/危重型组胸膜增厚的比例高于中型组(P=0.012)。中型组和重型/危重型组的右肺下叶肺叶评分均最高(2(1,3)和3(2,4))((M(Q)));重型/危重型组的总评分和各肺叶评分均高于中型组(P=0.001)。结论:对于合并基础病的新型冠状病毒Omicron变异株老年感染患者,胸部CT对肺内病变的临床分型、病情进展评估有重要价值,对临床治疗有一定指导意义。

     

    Abstract:
    Objective This study aimed to investigate the chest computed tomography (CT) findings of SARS-CoV-2 Omicron variants in elderly patients with underlying diseases.
    Methods We retrospectively analyzed data from 140 elderly patients with underlying diseases who were infected with SARS-CoV-2 Omicron variants. The patients were divided into a moderate group and a severe/critical group based on their clinical classifications. Clinical data, laboratory results, and chest CT data (including lesion distribution, morphology, image signs, and lung lobe score) were collected and analyzed for all patients.
    Results Hypertension and hyperlipidemia were the most prevalent underlying diseases among elderly patients with the Omicron variant of SARS-CoV-2. Ground-glass density opacity was the main chest CT manifestation, typically presenting as a mixed distribution across multiple lung lobes. Common clinical symptoms include fever, cough, and sputum production. The proportion of patients with fever was significantly higher in the severe/critical group compared to the moderate group (P=0.032). Additionally, the lymphocyte count was higher in the moderate group compared to the severe/critical group (P=0.037), while the procalcitonin level was significantly higher in the severe/critical group (P=0.001). Pleural thickening was also more prevalent in the severe/critical group (P=0.012). The right inferior lobe score was the highest in both groups (2 (1,3) and 3 (2,4) for moderate and severe/critical groups, respectively), with the total score and individual lobe scores being significantly higher in the severe/critical group (P=0.001).
    Conclusions Chest CT scans play a crucial role in classifying disease severity and evaluating disease progression in elderly patients with underlying diseases infected with the Omicron variant of the novel coronavirus. These findings can also guide clinical treatment decisions.

     

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