Abstract: Objective to explore the characteristics of the CT Hemo-perfusion for breast masses and its clinical value. Methods 22 patients with breast cancer and 11 breast benign lesions were all proven by surgeon or biopsy. ..Using a spiral plus 4(Light Speed ,GE Medical, Milwaukee, Wis)scanner an plain scan was performed through the anatomical region in question. Then sections through the tumor were selected.Using an injector pump 50ml of 300mg/100ml iovist contrast agent was injected via cubital vein at a rate 3.5ml/s,and 5s delay, then a multisection perfusion procedure was performed with a cine mode up to 55s.When these data transmitted to Advantage Workstation 4.1,the parameters of hemoperfusion such as BF、BV and PS in tumor peripheral zone and central portions, were acquired by a software package perfusion 3 within the Workstation. These values of hemoperfusion were analyzed statistically. Results The mean of BF、BV and PS in breast benign lesion, in tumor peripheral zone and central portions were (11.89±2.80)ml·min^-1·100g^-1,(1.24±0.52)ml·100g^-1,(3.41±1.09)ml·min-1·100g^-1, (38.68±7.21)ml·min^-1·100g^-1,(7.10±2.34)ml·100g^-1,(16.45±4.90)ml·min^-1·100g^-1(22.87±3.37)ml·min^-1·100g,(2.40±0.12)ml·100g^-1,(5.78±1.65)ml·min^-1·100g^-1, respectively. The mean BF, BV, and PS between breast cancer and breast benign lesion, between peripheral zone and central portions of tumor were statistically significant(p<0.05). Conclusions CT Hemoperfusion is an indirect reflection of biological behavior of breast tumor and has important value for the diagnosis and prognosis of breast cancer.