Abstract: Objective:Discussion of 16 slice spiral CT in the diagnosis of acute pancreatitis classification method and its clinical significance. Method:A retrospective analysis of 2009~2011 years of acute pancreatitis in 41 patients, male 23 cases, female 18 cases. All patients underwent CT plain scan and enhanced scan. Result:According to the CT severity index score, CTSI:According to the score will result in turn is divided into 3 grades:Light level (0~3) in 23 cases, accounting for 56.1%, intermediate (4~6) in 7 cases, accounting for 17.1%, heavy (7~10) in 11 cases, accounting for 26.8%. Conclusion:Spiral CT for the diagnosis of acute pancreatitis provides intuitive basis, CTSI not only can accurately reflect the severity of acute pancreatitis, and can accurately judge the severity of acute pancreatitis in early stage and prognosis of acute pancreatitis, clinical treatment and prognostic significance.