Abstract: In view of the X-ray ionizing radiation damage effects of CT,we propose a method of sparse-view reconstruction based on low-dose CT projection data to reduce the radiation dose.This method uses a penalized weighted least square(PWLS) method for low-dose CT projection denoise,and then reconstructs the CT image from few views of the de-noised projection data.Reconstruction results from a simulation experiment with a Shepp-Logan phantom and real experiment data show that:this method can effectively suppress noise and strip artifacts in reconstructed images,as well as reconstruct good quality images from low-dose few-view CT data.