Innovative Application-Specific All-Digital PET Systems
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摘要:
基于多电压阈值方法的全数字正电子发射断层成像（PET）技术以“全数字”和“精确采样”为两个本质特点，实现软硬件解耦、系统“乐高”化搭建，打破了传统PET系统架构固定的限制，为更多创新应用的开展提供了可能。本文介绍了近年来应用专用型全数字PET系统的研究进展，阐述其在质子治疗监测、脑科学临床与基础研究、植物代谢研究等领域中的应用及其优势。面对前沿应用对PET成像系统提出的更高要求，进一步探讨全数字PET技术的发展趋势。
Abstract:Utilizing the Multi-Voltage Threshold method, All-Digital PET technology, characterized by "All-Digital" and "accurate sampling," facilitates hardware and software decoupling and modular "LEGO-like" system construction. This innovation addresses the limitations of traditional PET system architectures, enabling a broader range of innovative applications. This paper reviews recent advancements in application-specific All-Digital PET systems, highlighting their applications and advantages in proton therapy monitoring, clinical and basic brain science research, and plant metabolism studies. Furthermore, we explore the development trends of All-Digital PET technology to meet the increasing demands of PET imaging applications.
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图 2 质子束辐照水假体及动物的活度分布图，第1行为在束成像结果，第2行为离束成像结果，第3行为图中黑色虚线范围内沿束流方向的平均一维活度分布，红色曲线代表在束一维活度分布，蓝色曲线代表离束一维活度分布，束流在图中从右向左入射[17]
Figure 2. Induced activity reconstruction irradiating a phantom (uniformly filled with water), mice, and rats. The first, second, and third rows present the beam-on imaging results, beam-off imaging results, and average one-dimensional activity distribution along the beam direction within the black dashed line in the figures, respectively. The red and blue lines represent the beam-on and beam-off settings. The beam was irradiated from right to left in the figures[17]
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图 3 脑部专用全数字PET探测器及原型机[29]
Figure 3. All-Digital PET detector for All-Digital brain PET and All-Digital brain PET prototype[29]
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图 6 68岁女性，采用AV-45示踪剂的脑内淀粉样蛋白的成像结果
Figure 6. Amyloid imaging in the brain using an AV-45 tracer in a 68-year-old woman
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图 9 “双动态”全数字PET各部分测试原型机与DOI探测器数据采集及测试平台[48]
Figure 9. All-Digital bi-dynamic PET instrument prototype of each part and DOI detector data acquisition and test platform[48]
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