Abstract: Objective To investigate the association of silent brain infarct (SBI), abdominal obesity and blood biochemical parameters in males. Methods The routine health check-up data in 645 senior managers of Kailuan Corporation were collected and analyzed. Using case-control study, waist circumference 〉 90cm as diagnostic criteria for abdominal obesity, the health check-up data will be divided into abdominal obesity group (n = 474) and normal waist circumference group (n = 171). Based on head CT, SBI (n = 170) was diagnosed. And fasting blood samples were taken to measure their blood glucose, blood lipid and other biochemical parameters. Association of abdominal obesity, silent brain infarct and blood biochemical parameters in males were analyzed. Results Age, hypertension, diabetes, abdominal obesity, systolic blood pressure, waist circumference, blood glucose and LDL-C levers were higher in SBI group than those in control group (P < 0.01, P < 0.05); Hypertension, SBI, BMI, blood glucose, TG levers and the drinking rates were higher in abdominal obesity group than those in normal waist circumference group (P < 0.01, P <0.05). Moreover, age and HDL-C levers were lower in abdominal obesity group than in normal waist circumference group (P < 0.01). Multivariate stepwise regression analysis showed that abdominal obesity and systolic blood pressure were associated with SBI (P <0.01, P <0.05). Conclusion Abdominal obesity and systolic blood pressure may be independent risk factors for patients with SBI.