ISSN 1004-4140
CN 11-3017/P
LV L, ZHAI J, LI Y C, et al. Quantitative CT Analysis of Body Composition in Maintenance Hemodialysis Patients[J]. CT Theory and Applications, 2023, 32(2): 256-262. DOI: 10.15953/j.ctta.2022.050. (in Chinese).
Citation: LV L, ZHAI J, LI Y C, et al. Quantitative CT Analysis of Body Composition in Maintenance Hemodialysis Patients[J]. CT Theory and Applications, 2023, 32(2): 256-262. DOI: 10.15953/j.ctta.2022.050. (in Chinese).

Quantitative CT Analysis of Body Composition in Maintenance Hemodialysis Patients

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  • Received Date: March 21, 2022
  • Accepted Date: June 24, 2022
  • Available Online: June 29, 2022
  • Published Date: March 30, 2023
  • This study analyzes body composition information in patients on maintenance hemodialysis and explores the application value of QCT technology. Methods: A total of 62 patients on maintenance hemodialysis were selected and divided into three groups according to different dialysis durations. The bone density value, abdominal fat, and muscle content of patients were determined by quantitative CT technology and 62 cases of the health examination population matched by sex and age were selected for comparative analysis. Results: In the dialysis group, osteoporosis accounted for 17.70% (11 cases) and bone loss accounted for 30.60% (19 cases), while in the healthy control group, osteoporosis and bone loss accounted for 6.50% (4 cases) and 16.10% (10 cases), respectively. The difference between these two groups was statistically significant. Moreover, the intra-abdominal and subcutaneous fat content in the dialysis group were (113.70±63.29)cm² and (80.65±59.67)cm², respectively, which were lower than that of the healthy control group ((135.90±58.80)cm² and (122.26±54.94)cm², respectively). Additionally, the dialysis group had a significantly lower L3-SMA (107.00±30.70)cm² than the control group (121.37±32.87)cm², and the lumbar vertebral bone density value was significantly lower in male dialysis patients (156.11±51.94)mg/cm³ than in female dialysis patients (124.29±50.89)mg/cm³. Moreover, the subcutaneous fat content was significantly higher in females than in males; however, the difference in intraperitoneal fat content between males and females was not statistically significant. Additionally, the difference between bone density values and L3-SMA changes in the dialysis group and the length of dialysis time were not statistically significant. Conclusion: The incidence of osteoporosis is higher in patients on maintenance hemodialysis than in healthy people, and the amount of abdominal fat and muscle content are lower than that in healthy people. Moreover, quantitative CT body composition monitoring has high accuracy and sensitivity.
  • [1]
    ZAYOUR D, DAOUK M, MEDAWAR W, et al. Predictors of bone mineral, density in patients on hemodialysis[J]. TranspIanlation Proceedings, 2004, 36(5): 1297−1301. doi: 10.1016/j.transproceed.2004.05.069
    [2]
    WU C C, LIOU H H, SU P F, et al. Abdominal obesity is the most significant metabolic syndrome component predictive of cardiovascular events in chronic hemodialysis patients[J]. Nephrol Dial Transplant, 2011, 26: 3689−3695. doi: 10.1093/ndt/gfr057
    [3]
    程晓光, 王亮, 曾强, 等. 中国定量CT (QCT)骨质疏松症诊断指南(2018)[J]. 中国骨质疏松杂志, 2019,25(6): 733−737.

    CHENG X G, WANG L, ZENG Q, et al. The China guideline for the diagnosis criteria of oste oporosis with quantitative computed tomography (QCT) (2018)[J]. Chinese Journal of Osteoporosis, 2019, 25(6): 733−737. (in Chinese).
    [4]
    夏维波, 章振林, 林华, 等. 原发性骨质疏松症诊疗指南(2017)[J]. 中国骨质疏松杂志, 2019,25(3): 281−309. doi: 10.3969/j.issn.1006-7108.2019.03.001

    XIA W B, ZHANG Z L, LIN H, et al. Guidelines for the diagnosis and management of primary osteoporosis (2017)[J]. Chinese Journal of Osteoporosis, 2019, 25(3): 281−309. (in Chinese). doi: 10.3969/j.issn.1006-7108.2019.03.001
    [5]
    胡耀, 黄朝莉, 徐秀蓉. 维持性血液透析患者骨密度测定与相关指标分析[J]. 现代临床医学, 2012,38(1): 13−14. doi: 10.3969/j.issn.1673-1557.2012.01.005

    HU Y, HUANG Z L, XU X R. To analysis bone mineral density and related indicators in patients of maintaining hemodialysis[J]. Journal of Modern Clinical Medicine, 2012, 38(1): 13−14. (in Chinese). doi: 10.3969/j.issn.1673-1557.2012.01.005
    [6]
    MOSCOVICI A, SPRAGUE S M. Osteoprosis and chronic kidney disease[J]. Seminars in Dialysis, 2007, 20(5): 423−430. doi: 10.1111/j.1525-139X.2007.00319.x
    [7]
    刘铁滨, 王维. 长期血液透析患者腰椎骨密度定量CT的检测及意义[J]. 实用放射学杂志, 2004,20(12): 1104−106. doi: 10.3969/j.issn.1002-1671.2004.12.014

    LIU T B, WANG W. Measurement of lumbar bone mineral density with quantitative computed tomography in hemodialysis patients[J]. Journal of Practical Radiology, 2004, 20(12): 1104−106. (in Chinese). doi: 10.3969/j.issn.1002-1671.2004.12.014
    [8]
    MIRFAKHRAEE S, SAKHAEE K, ZERWEKH J, et al. Risk factors for diminished bone mineral density among male hemodialysis patients: A cross-sectional study[J]. Arch Osteoporos, 2012, 7(1/2): 283−290. doi: 10.1007/s11657-012-0110-3
    [9]
    SHEU Y, MARSHALL L M, HOLTON K F, et al. Abdominal body composition measured by quantitative computed tomography and risk of non-spine fractures: The osteoporotic fractures in men (MrOS) study[J]. Osteoporosis International, 2013, 24(8): 2231−2241. doi: 10.1007/s00198-013-2322-9
    [10]
    CHENG X, ZHANG Y, WANG C, et al. The optimal anatomic sitefor a single slice to estimate the total volume of visceraladipose tissue by using the quantitative computed tomography (QCT) in Chinese population[J]. European Journal of Clinical Nutrition, 2018, 72(11): 1567−1575. doi: 10.1038/s41430-018-0122-1
    [11]
    丁奕, 田娜, 周晓玲, 等. 肥胖与IgA肾病患者独立肾脏风险因子的相关性分析[J]. 中华肾脏病杂志, 2017,33(5): 321−326. doi: 10.3760/cma.j.issn.1001-7097.2017.05.001

    DING Y, TIAN N, ZHOU X L, et al. Correlation analysis of obesity with independent renal risk factors in patients with IgA nephropathy[J]. Chinese Journal of Nephrology, 2017, 33(5): 321−326. (in Chinese). doi: 10.3760/cma.j.issn.1001-7097.2017.05.001
    [12]
    刘建强, 贾冶, 许钟镐, 等. 肥胖与慢性肾脏疾病: 脂肪组织与肾脏炎症及纤维化的关系[J]. 中华肾脏病杂志, 2017, 33(12): 956-960.

    LIU J Q, JIA Y, XU Z H, et al. Obesity and chronic kidney disease: The relationship between adipose tissue and kidney inflammation and fibrosis[J]. Chinese Journal of Nephrology, 2017, 33(12): 956-960. (in Chinese).
    [13]
    罗文荣, 姚书东, 孙梅琴. 血液透析对肾病肥胖女性患者内分泌相关指标的影响[J]. 中国妇幼保健, 2021,36(14): 3195−3198. DOI: 10.19829/j.zgfybj.issn.1001-4411.2021.14.009.

    LUO W R, YAO S D, SUN M Q. Effect of hemodialysis on endocrine-related indicators in obese women with kidney disease[J]. Maternal and Child Health Care of China, 2021, 36(14): 3195−3198. DOI: 10.19829/j.zgfybj.issn.1001-4411.2021.14.009. (in Chinese).
    [14]
    晏乘曦, 唐光才, 程晓光. 肌少症的定量测量现状及研究进展[J]. 中国骨质疏松杂志, 2018,24(6): 814−819. doi: 10.3969/j.issn.1006-7108.2018.06.021

    YAN C X, TANG G C, CHENG X G. State of the art of quantitative me asurement of sarcopenia[J]. Chinese Journal of Osteoporosis, 2018, 24(6): 814−819. (in Chinese). doi: 10.3969/j.issn.1006-7108.2018.06.021
    [15]
    耿楠, 孔明, 陈煜, 等. 第三腰椎骨骼肌指数在终末期肝病营养诊断中的应用价值[J]. 临床肝胆病杂志, 2021,37(10): 2493−2496. doi: 10.3969/j.issn.1001-5256.2021.10.050

    GENG N, KONG M, CHENG Y, et al. Value of L3 skeletal muscle index in nutritional diagnosis of end-stage liver disease[J]. Journal of Clinical Hepatology, 2021, 37(10): 2493−2496. (in Chinese). doi: 10.3969/j.issn.1001-5256.2021.10.050
    [16]
    FAHAL I H. Uraemic sareopenia: Aetiology and implications[J]. Nephml Dial Transplant, 2014, 29(9): 1655−1665. doi: 10.1093/ndt/gft070
    [17]
    PRADO C M, LIEFFERS J R, MCCARGAR L J, et al. Prevalence andclinical implications of sarcopenic obesity in patients with solidtumours of the respiratory and gastrointestinal tracts: Apopulation-based study[J]. Lancet Oncology, 2008, 9(7): 629. doi: 10.1016/S1470-2045(08)70153-0

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