ISSN 1004-4140
CN 11-3017/P
Volume 31 Issue 3
Jun.  2022
Turn off MathJax
Article Contents
ZHAI X L, WANG L X, LI X. Clinical imaging characteristics and pathological features of sarcomatoid hepatocellular carcinoma[J]. CT Theory and Applications, 2022, 31(3): 409-416. DOI: 10.15953/j.ctta.2022.057. (in Chinese)
Citation: ZHAI X L, WANG L X, LI X. Clinical imaging characteristics and pathological features of sarcomatoid hepatocellular carcinoma[J]. CT Theory and Applications, 2022, 31(3): 409-416. DOI: 10.15953/j.ctta.2022.057. (in Chinese)

Clinical Imaging Characteristics and Pathological Features of Sarcomatoid Hepatocellular Carcinoma

doi: 10.15953/j.ctta.2022.057
  • Received Date: 2022-04-08
  • Accepted Date: 2022-04-14
  • Rev Recd Date: 2022-04-14
  • Available Online: 2022-04-15
  • Publish Date: 2022-05-23
  • Objective: To explore the imaging manifestations and clinical-pathological features of sarcomatoid hepatocellular carcinoma (SHC). Methods: The clinical data, CT/MRI findings and pathological features of 7 patients with SHC were retrospectively analyzed and the consistency was evaluated. Results: SHC showed unclear boundary and low density by plain CT images, with the size ranging from 4.2 cm×4.7 cm–14.0 cm×11.0 cm. By enhanced CT images, SHC showed ring or early enhancement with large areas of necrosis. SHC showed heterogeneous signal intensity on T1WI and T2WI with visible cystic degeneration and necrotic area while DWI displayed obvious diffusion restricted changes. On enhanced MRI, the tumor showed progressive enhancement of peripheral and solid components with delayed enhanced pseudo-capsule. 6 cases had different degree of necrosis in the center of lesion, and lymph node metastasis in the livers hilar was found in 5 patients. Pathological features polygonal and fusiform tumor cells with extensive necrosis and hemorrhage were found on HE staining. Vimentin and CK were positive by immunohistochemical staining. Conclusions: The imaging findings of SHC were consistent with the pathological features, which was helpful to deep understanding of specific imaging manifeatations, and the diagnosis and differential diagnosis of liver tumors.

     

  • loading
  • [1]
    LIAO S H, SU T H, JENG Y M, et al. Clinical manifestations and outcomes of patients with sarcomatoid hepatocellular carcinoma[J]. Hepatology (Baltimore, Md), 2019, 69(1): 209−221. DOI: 10.1002/hep.30162.
    [2]
    YOSHIDA N, MIDORAKAWA Y, KAJIWARA T, et al. Hepatocellular carcinoma with sarcomatoid change without anticancer therapies[J]. Case Reports in Gastroenterology, 2013, 7(1): 169−174. DOI: 10.1159/000350558.
    [3]
    WANG J P, YAO Z G, SUN Y W, et al. Clinicopathological characteristics and surgical outcomes of sarcomatoid hepatocellular carcinoma[J]. World Journal Gastroenterology, 2020, 26(29): 4327−4342. DOI: 10.3748/wjg.v26.i29.4327.
    [4]
    KAN A, GUO R P. The prognosis of subsequent surgical treatment in patients with sarcomatoid carcinoma in the liver: A retrospective study[J]. International Journal of Surgery, 2018, 55: 145−151. DOI: 10.1016/j.ijsu.2018.05.736.
    [5]
    李琛, 王华颖, 李琳琳, 等. 消化系统肉瘤样癌22例临床病理分析[J]. 临床与实验病理学杂志, 2020,36(10): 108−111. doi: 10.13315/j.cnki.cjcep.2020.10.026
    [6]
    YANG Z, LV K, ZHAO Y, et al. Sarcomatoid hepatocellular carcinoma mimicking hepatic abscess: A case report[J]. Medicine, 2020, 99(39): e22489. DOI: 10.1097/MD.0000000000022489.
    [7]
    ERIGUCHI N, AOYAGI S, OKUDA K, et al. Unusual liver carcinomas with sarcomatous features: Analysis of four cases[J]. Surgery Today, 2001, 31(6): 530−533. DOI: 10.1007/s005950170116.
    [8]
    WANG Q B, CUI B K, WENG J M, et al. Clinicopathological characteristics and outcome of primary sarcomatoid carcinoma and carcinosarcoma of the liver[J]. Journal of Gastroin-testinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract, 2012, 16(9): 1715−1726. DOI: 10.1007/s11605-012-1946-y.
    [9]
    贺亚琼, 姚景江, 刘建滨, 等. 肝肉瘤样癌的病理及影像表现[J]. 中华放射学杂志, 2014,048(011): 956−958. doi: 10.3760/cma.j.issn.1005-1201.2014.11.019
    [10]
    SHI D, SUN J, MA L, et al. Clinical and imaging characteristics of primary hepatic sarcomatoid carcinoma and sarcoma: A comparative study[J]. BMC Cancer, 2020, 20(1): 977. DOI: 10.1186/s12885-020-07475-z.
    [11]
    徐莹莹, 谢道海. 原发性肝肉瘤样癌的影像表现与临床病理特征[J]. 实用放射学杂志, 2019,35(10): 1698−1701. DOI: 10.3969/j.issn.1002-1671.2019.10.037.

    XU Y Y, XIE D H. Imaging findings and clinical pathological features of primary hepatic sarcomatoid carcinoma[J]. Journal of Practical Radiology, 2019, 35(10): 1698−1701. DOI: 10.3969/j.issn.1002-1671.2019.10.037. (in Chinese).
    [12]
    王亚龙, 郭华, 蔡明珠. 肝肉瘤样癌的多层螺旋CT与病理特征[J]. 实用放射学杂志, 2019,35(5): 756−785, 802. DOI: 10.3969/j.issn.1002-1671.2019.05.017.

    WANG Y L, GUO H, CAI M Z. The MSCT and pathological features of sarcomatoid hepatocellular carcinoma[J]. Journal of Practical Radiology, 2019, 35(5): 756−785, 802. DOI: 10.3969/j.issn.1002-1671.2019.05.017. (in Chinese).
    [13]
    翁燕香, 陈正华, 陈少珍. 肉瘤样肝细胞癌的影像学表现[J]. 实用放射学杂志, 2016,(2): 314−316. DOI: 10.3969/j.issn.1002-1671.2016.02.045.

    WENG Y X, CHEN Z H, CHEN S Z. The image features of sarcomatoid hepatocellular carcinoma[J]. Journal of Practical Radiology, 2016, (2): 314−316. DOI: 10.3969/j.issn.1002-1671.2016.02.045. (in Chinese).
    [14]
    史东立, 马良, 赵大伟, 等. 原发性肝脏肉瘤的影像学表现[J]. 实用放射学杂志, 2018,34(10): 1538−1541, 1587. DOI: 10.3969/j.issn.1002-1671.2018.10.014.

    SHI D L, MA L, ZHAO D W, et al. Imaging findings of primary hepatic sarcoma[J]. Journal of Practical Radiology, 2018, 34(10): 1538−1541, 1587. DOI: 10.3969/j.issn.1002-1671.2018.10.014. (in Chinese).
    [15]
    KOO H R, PARK M S, KIM M J, et al. Radiological and clinical features of sarcomatoid hepatocellular carcinoma in 11 cases[J]. Journal of Computer Assisted Tomography, 2008, 32(5): 745−749. DOI: 10.1097/RCT.0b013e3181591ccd.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(2)  / Tables(1)

    Article Metrics

    Article Views(75) PDF Downloads(6) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return