ISSN 1004-4140
CN 11-3017/P
Volume 32 Issue 2
Mar.  2023
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Abstract
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ZHU N J, FANG X X, YIN Y J, et al. Risk Factors of Plaque Progression in Patients with Angina Pectoris and Their Relationships with Coronary CT Angiography[J]. CT Theory and Applications, 2023, 32(2): 217-222. DOI: 10.15953/j.ctta.2022.219. (in Chinese).
Citation: ZHU N J, FANG X X, YIN Y J, et al. Risk Factors of Plaque Progression in Patients with Angina Pectoris and Their Relationships with Coronary CT Angiography[J]. CT Theory and Applications, 2023, 32(2): 217-222. DOI: 10.15953/j.ctta.2022.219. (in Chinese).
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Risk Factors of Plaque Progression in Patients with Angina Pectoris and Their Relationships with Coronary CT Angiography

  • Department of Radiology, The 909th Hospital of joint Logistic Support Force (Dongnan Hospital of Xiamen University) , Zhangzhou 363000, China

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  • Received Date: November 08, 2022
  • Accepted Date: January 06, 2023
  • Available Online: January 10, 2023
  • Published Date: March 30, 2023
    Graphical Abstract
    • Abstract
  • Objective: To investigate the risk factors of plaque progression in patients with angina pectoris and their relationships with coronary computed tomography (CT) angiography. Methods: Clinical data of 236 patients with angina pectoris were retrospectively analyzed from January 2017 to January 2020. All patients were grouped according to whether plaque progression occurred, and the general information and coronary CT angiography indexes were compared between the two groups. A logistic regression model was used to evaluate the independent risk factors of plaque progression in patients with angina pectoris. The receiver operating characteristic (ROC) curve was delineated to analyze the clinical value of the prediction model based on coronary CT angiography indicators in predicting plaque progression risk. Results: There were significant differences in sex, the proportion of hyperlipidemia, proportion of statins, degree of stenosis, minimum lumen area, total plaque volume, RI, and CT-derived fractional flow reserve (FFR) between the two groups. The results of single factor analysis showed that the degree of stenosis, the minimum lumen area, plaque volume, the volume of non-calcified plaque, RI, and CT-FFR levels were related to the plaque progression in patients with angina pectoris. Univariate analysis showed that the degree of stenosis, minimum lumen area, plaque volume, non-calcified plaque volume, RI, and CT-FFR levels were associated with plaque progression in patients with angina pectoris. Multivariate analysis showed that RI and CT-FFR levels were independent factors of plaque progression in patients with angina pectoris. ROC curve analysis showed that the combination of stenosis degree + RI + CT-FFR was better than that of simple stenosis degree and stenosis degree + RI in predicting the area under the curve of plaque progression. Conclusion: RI and CT-FFR levels are important factors leading to plaque progression in patients with angina pectoris. The prediction model based on RI and CT-FFR can more accurately identify plaque progression.
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    • References (17)
  • [1]
    高艳, 顾慧, 杨世锋, 等. 基于冠状动脉CT血管成像的斑块定量分析及其与心肌缺血损伤的相关性研究[J]. 中华放射学杂志, 2020,54(2): 129−135. doi: 10.3760/cma.j.issn.1005-1201.2020.02.008

    GAO Y, GU H, YANG S F, et al. Correlation study of coronary plaque quantitative analysis and myocardial ischemic injury based on coronary CT angiography[J]. Chinese Journal of Radiology, 2020, 54(2): 129−135. (in Chinese). doi: 10.3760/cma.j.issn.1005-1201.2020.02.008
    [2]
    ZHAN R, QI R, HUANG S, et al. The correlation between hepatic fat fraction evaluated by dual-energy computed tomography and high-risk coronary plaques in patients with non-alcoholic fatty liver disease[J]. Japanese Journal of Radiology, 2021, 5(4): 1123−1130.
    [3]
    KIM U, LEIPSIC J A, SELLERS S L, et al. Natural history of diabetic coronary atherosclerosis by quantitative measurement of serial coronary computed tomographic angiography: Results of the PARADIGM study[J]. Journal of the American College of Cardiology Cardiovasc Imaging, 2018, 11(10): 1461−1471. doi: 10.1016/j.jcmg.2018.04.009
    [4]
    KLÜNER L V, OIKONOMOU E K, ANTONIADES C. Assessing cardiovascular risk by using the fat attenuation index in coronary CT angiography[J]. Radiology Cardiothoracic Imaging, 2021, 3(1): e200563. doi: 10.1148/ryct.2021200563
    [5]
    YAMAMOTO M H, YAMASHITA K, MATSUMURA M, et al. Serial 3-vessel optical coherence tomography and intravascular ultrasound analysis of changing morphologies associated with lesion progression in patients with stable angina pectoris[J]. Circulation-Cardiovascular Imaging, 2017, 10(9): e006347. doi: 10.1161/CIRCIMAGING.117.006347
    [6]
    MEAH M N, WILLIAMS M C. Clinical relevance of coronary computed tomography angiography beyond coronary artery stenosis[J]. Rofo-fortschr Rontg, 2021, 26(3): 1174−1183.
    [7]
    KITAHARA S, KATAOKA Y, MIURA H, et al. The feasibility and limitation of coronary computed tomographic angiography imaging to identify coronary lipid-rich atheroma in vivo: Findings from near-infrared spectroscopy analysis[J]. Atherosclerosis, 2021, 322(4): 1−7.
    [8]
    TESCHE C, de CECCO C N, ALBRECHT M H, et al. Coronary CT angiography-derived fractional flow reserve[J]. Radiology, 2017, 285(1): 17−33. doi: 10.1148/radiol.2017162641
    [9]
    YANG L, XU P P, SCHOEPF U J, et al. Serial coronary CT angiography-derived fractional flow reserve and plaque progression can predict long-term outcomes of coronary artery disease[J]. European Radiology, 2021, 25(2): 1156−1163.
    [10]
    KOLOSSVÁRY M, GERSTENBLITH G, BLUEMKE D A, et al. Contribution of risk factors to the development of coronary atherosclerosis as confirmed via coronary CT angiography: A longitudinal radiomics-based study[J]. Radiology, 2021, 299(1): 97−106. doi: 10.1148/radiol.2021203179
    [11]
    LIU X, WU G, XU C, et al. Prediction of coronary plaque progression using biomechanical factors and vascular characteristics based on computed tomography angiography[J]. Computer Assistant Surgery (Abingdon), 2017, 22(S1): 286−294.
    [12]
    BENTON S M, TESCHE C, DE CECCO C N, et al. Noninvasive derivation of fractional flow reserve from coronary computed tomographic angiography: A review[J]. Journal of Thoracic Imaging, 2018, 33(2): 88−96. doi: 10.1097/RTI.0000000000000289
    [13]
    LEE S E, CHANG H J, SUNG J M, et al. Effects of statins on coronary atherosclerotic plaques: The PARADIGM study[J]. Journal of the American College of Cardiology Cardiovasc Imaging, 2018, 11(10): 1475−1484. doi: 10.1016/j.jcmg.2018.04.015
    [14]
    CICCARELLI G, BARBATO E, TOTH G G, et al. Angiography versus hemodynamics to predict the natural history of coronary stenoses: Fractional flow reserve versus angiography in multivessel evaluation 2 substudy[J]. Circulation, 2018, 137(14): 1475−1485. doi: 10.1161/CIRCULATIONAHA.117.028782
    [15]
    TANG C X, WANG Y N, ZHOU F, et al. Diagnostic performance of fractional flow reserve derived from coronary CT angiography for detection of lesion-specific ischemia: A multi-center study and meta-analysis[J]. European Journal of Radiology, 2019, 116(10): 90−97.
    [16]
    IMAI S, KONDO T, STONE G W, et al. Abnormal fractional flow reserve in nonobstructive coronary artery disease[J]. Circulation Cardiovascular Intervention, 2019, 12(2): e006961. doi: 10.1161/CIRCINTERVENTIONS.118.006961
    [17]
    NOZUE T, TAKAMURA T, FUKUI K, et al. Changes in coronary atherosclerosis, composition, and fractional flow reserve evaluated by coronary computed tomography angiography in patients with type 2 diabetes[J]. International Journal of Cardiology Heart Vascular, 2018, 19(4): 46−51.
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