ISSN 1004-4140
CN 11-3017/P
Volume 21 Issue 4
Dec.  2012
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Hengyong Yu, Qiong Xu, Peng He, James Bennett, Raja Amir, Bruce Dobbs, MOU Xuan-qin, WEI Biao, Anthony Butler, Phillip Butler, Ge Wang. Medipix-based Spectral Micro-CT[J]. CT Theory and Applications, 2012, 21(4): 583-596.
Citation: Hengyong Yu, Qiong Xu, Peng He, James Bennett, Raja Amir, Bruce Dobbs, MOU Xuan-qin, WEI Biao, Anthony Butler, Phillip Butler, Ge Wang. Medipix-based Spectral Micro-CT[J]. CT Theory and Applications, 2012, 21(4): 583-596.
shu

Medipix-based Spectral Micro-CT

  • 1. Department of Radiology, Division of Radiologic Sciences, Wake Forest University Health Sciences, Winston-Salem, NC, 27157, USA;

  • 2. Biomedical Imaging Division, VT-WFU School of Biomedical Engineering and Sciences, Wake Forest University Health Sciences, Winston-Salem, NC, 27157, USA;

  • 3. Biomedical Imaging Division, VT-WFU School of Biomedical Engineering and Sciences, Virginia Tech, Blacksburg, VA 24061, USA;

  • 4. Institute of Image Processing and Pattern Recognition, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China;

  • 5. The Key Lab of Optoelectronic Technology and Systems of the Education Ministry of China, Chongqing University, Chongqing, 400044, China;

  • 6. Department of Physics and Astronomy, University of Canterbury, Christchurch, 8140, New Zealand;

  • 7. Department of Surgery and Gastroenterology, University of Otago, Christchurch, 8140, New Zealand;

  • 8. Department of Radiology, University of Otago, Christchurch, 8140, New Zealand;

  • 9. European Organization for Nuclear Research(CERN), Geneva, Switzerland

Funds: 

supported in part by NIH/NIBIB grant EB011785,the Ministry of Science and Innovation(New Zealand),a seed grant from Wake Forest Institute for Regenerative Medicine

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  • Received Date: June 07, 2012
  • Available Online: December 12, 2022
    Graphical Abstract
    • Abstract
  • Since Hounsfield's Nobel Prize winning breakthrough decades ago, X-ray CT has been widely applied in the clinical and preclinical applications-producing a huge number of tomographic gray-scale images. However, these images are often insufficient to distinguish crucial differences needed for diagnosis. They have poor soft tissue contrast due to inherent photon-count issues, involving high radiation dose. By physics, the X-ray spectrum is polychromatic, and it is now feasible to obtain multi-energy, spectral, or true-color, CT images. Such spectral images promise powerful new diagnostic information. The emerging Medipix technology promises energy-sensitive, high-resolution, accurate and rapid X-ray detection. In this paper, we will review the recent progress of Medipix-based spectral micro-CT with the emphasis on the results obtained by our team. It includes the state-of-the-art Medipix detector, the system and method of a commercial MARS (Medipix All Resolution System) spectral micro-CT, and the design and color diffusion of a hybrid spectral micro-CT.
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