CT Findings of Pulmonary Lymphomatoid Granulomatosis

Objective: To investigate characteristic CT findings of pulmonary lymphomatoid granulomatosis and to improve the knowledge of this disease. Methods: CT imaging data of 8 pathologically confirmed pulmonary lymphomatoid granulomatosis cases were retrospectively reviewed, including 3 men and 5 women, the average age was 42 years. Five of the cases underwent contrast enhanced scan. Results: Histologically, two patients were grade l, four were grade 2 and two were grade 3. Six patients showed multiple lesions on CT images, one of which showed multiple nodules, four cases showed mainly multiple nodules or masses with varying amounts of patchy lesions, and one patient was mainly patchy lesion with a few small nodules. Two patients showed solitary nodule or mass on CT images; Three patients showed lower hmg preponderance, three patients were upper lung preponderance, the other two patients showed lesions in both upper and lower lung. In the six patients with multiple lesions, the lesions distributed along the peribronchovascular huddle, five of which showed subpleural lesions. Nodules and masses in all patients showed coarse margin, with halo sign. Four patients showed low attenuation center. Air bronchograms were seen in three cases. Cavitation was seen in one case. All the five cases with contrast enhanced scan showed ring-like peripheral enhancement. Lymphadenopathy were seen in 5 patients, the average enhancement of center was 13.2Hu. Conclusions: Multiple nodules or masses with peribronchovascular and subpleural distribution, accompanied by halo sign and ring-like peripheral enhancement are common CT manifestations of LYG.