ISSN 1004-4140
CN 11-3017/P
Volume 27 Issue 5
Oct.  2018
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CHEN Tao, YANG Tao, CHENG Jing-liang, LIU Kang-yong, GU Jing-hua, ZHANG Chun-yan, ZHANG Ye. The Application of DTI and SWI for Substantia Nigra in Early Primary Parkinson's Disease[J]. CT Theory and Applications, 2018, 27(5): 635-641. DOI: 10.15953/j.1004-4140.2018.27.05.10
Citation: CHEN Tao, YANG Tao, CHENG Jing-liang, LIU Kang-yong, GU Jing-hua, ZHANG Chun-yan, ZHANG Ye. The Application of DTI and SWI for Substantia Nigra in Early Primary Parkinson's Disease[J]. CT Theory and Applications, 2018, 27(5): 635-641. DOI: 10.15953/j.1004-4140.2018.27.05.10
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The Application of DTI and SWI for Substantia Nigra in Early Primary Parkinson's Disease

  • 1. Department of Imaging, Dongfeng General Hospital of Chinese Medicine, Affiliated to Hubei University of Medicine, Shiyan 442000, China;

  • 2. a). Department of Imaging, b). Department of neurology, Zhoupu Hospital, Affiliated to Shanghai University of Medicine & Health Sciences, Shanghai 201318, China;

  • 3. Department of MRI, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

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  • Received Date: May 29, 2018
  • Available Online: November 07, 2021
  • Published Date: October 24, 2018
    Graphical Abstract
    • Abstract
  • Objective: To investigate the application of diffusion tensor imaging (DTI) and susceptibility weighted imaging (SWI) in the changes of substantia nigra in patients with early primary Parkinson's disease. Methods: Conventional sequence, DTI, and SWI scans were performed on 13 patients with early primary Parkinson's disease and 13 volunteers as controls using a 3 T magnetic resonance imaging system. The FA and ADC values of the substantia nigra of the two groups and the size of the substantia nigra pars compacta were measured. Results: The FA values of bilateral substantia nigra were reduced in the PD group compared with the control group, the difference was statistically meaning (P<0.05). There was no significant difference in the ADC values of the substantia nigra between the two groups (P>0.05). The size of the substantia nigra pars compact in the PD group was smaller than that in the control group, the difference was statistically meaning (P<0.05). Conclusions: The FA value of the substantia nigra and the size of the substantia nigra pars compacta contribute to the early diagnosis of PD. DTI and SWI have a synergistic effect and may provide valuable clues for the early diagnosis of PD.
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