ISSN 1004-4140
CN 11-3017/P
Volume 31 Issue 5
Sep.  2022
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DONG J K, DENG M, YANG T, et al. The study of diffusion kurtosis imaging on microstructural changes of substantianigra in patients with early parkinson's disease[J]. CT Theory and Applications, 2022, 31(5): 623-629. DOI: 10.15953/j.ctta.2022.010. (in Chinese).
Citation: DONG J K, DENG M, YANG T, et al. The study of diffusion kurtosis imaging on microstructural changes of substantianigra in patients with early parkinson's disease[J]. CT Theory and Applications, 2022, 31(5): 623-629. DOI: 10.15953/j.ctta.2022.010. (in Chinese).
shu

The Study of Diffusion Kurtosis Imaging on Microstructural Changes of Substantianigra in Patients with Early Parkinson's Disease

  • 1.

    The First People’s Hospital of Kashi Prefecture, Kashi 844000, China

  • 1.

    Affiliated to Shanghai University of Medicine & Health Sciences, Shanghai 201318, China Department of Imaging

  • 2.

    Affiliated to Shanghai University of Medicine & Health Sciences, Shanghai 201318, China Department of neurology, Zhoupu Hospital

  • 3.

    Image Center, ShacheCountyPeople’s Hospital of Kashi Prefecture, Shache 844799, China

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  • Received Date: January 16, 2022
  • Accepted Date: March 27, 2022
  • Available Online: April 10, 2022
  • Published Date: September 30, 2022
    Graphical Abstract
    • Abstract
  • Objective: To explore the diagnostic value of diffusion kurtosis imaging (DKI) the microstructure changes of substantianigra in patients with early Parkinson's disease (PD). Methods: 30 patients with early PD were collected as the PD group while 20 healthy volunteers as the control group. All the subjects underwent brain routine magnetic resonance imaging (MRI) and DKI examination. The DKI scan data were processed to obtain quantitative parameter maps, with the three paramrters as fractional anisotropy (FA), mean diffusivity (MD) and mean kurtosis (MK). The DKI parameters of substantianigra (SN) were measured respectively and the differences between the two groups were statistically analyzed. The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficacy of DKI parameters in patients with early PD. Results: The FA value of the substantianigra of the PD group was lower than that of the healthy control group, and the difference between the two groups was statistically significant. Compared with the healthy control group, the MD value of the substantianigra in the PD group was slightly higher, and the difference between the two groups was not statistically significant. The MK value of the substantianigra in the PD group was significantly higher than that in the healthy control group, and the difference between the two groups was statistically significant. The ROC curve showed the AUC of FA value, MD value and MK value in the substantianigra in the diagnosis of early PD were 0.716, 0.613 and 0.820, respectively. The substantianigra MK value showed certain accuracy in the diagnosis of early PD patients, and the diagnostic sensitivity and specificity were higher than the FA value and MD value. Conclusions: DKI can be used to analyze the changes of the microstructure of substantianigra in early PD patients, and the MK value can better reflect the changes of the microstructure of substantianigra in early PD patients.
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  • [1]
    孙崎元, 孟妲, 张铎. 磁共振扩散峰度成像与定量磁敏感图对帕金森病诊断的初步研究[J]. 实用放射学杂志, 2018,34(11): 1655−1659. doi: 10.3969/j.issn.1002-1671.2018.11.001

    SUN Q Y, MENG D, ZHANG D. Preliminary study of magnetic resonance diffusion kurtosis imaging and quantitative susceptibility to the diagnosis of Parkinson's disease[J]. Journal of Practical Radiology, 2018, 34(11): 1655−1659. (in Chinese). doi: 10.3969/j.issn.1002-1671.2018.11.001
    [2]
    FERACO P, GAGLIARDO C, La TONA G, et al. Imaging of substantianigra in Parkinson's disease: A narrative review[J]. Brain Science, 2021, 11(6): 769. doi: 10.3390/brainsci11060769
    [3]
    杨涛, 张春艳, 程敬亮, 等. 磁共振弥散张量成像在早期帕金森病诊断中的应用研究[J]. CT理论与应用研究, 2017,26(1): 85−89. DOI: 10.15953/j.1004-4140.2017.26.01.11.

    YANG T, ZHANG C Y, CHENG J L, et al. Application of diffusion tensor imaging in the early diagnosis of Parkinson's disease[J]. CT Theory and Applications, 2017, 26(1): 85−89. DOI: 10.15953/j.1004-4140.2017.26.01.11. (in Chinese).
    [4]
    陈涛, 杨涛, 程敬亮, 等. DTI及SWI在早期原发性帕金森病患者脑黑质改变中的应用研究[J]. CT理论与应用研究, 2018,27(5): 635−641. DOI: 10.15953/j.1004-4140.2018.27.05.10.

    CHEN T, YANG T, CHENG J L, et al. The application of DTI and SWI for substantia nigra in early primary Parkinson's disease[J]. CT Theory and Applications, 2018, 27(5): 635−641. DOI: 10.15953/j.1004-4140.2018.27.05.10. (in Chinese).
    [5]
    中华医学会神经病学分会帕金森病及运动障碍学组, 中国医师协会神经内科医师分会帕金森病及运动障碍专业委员会. 中国帕金森病的诊断标准(2016版)[J]. 中华神经科杂志, 2016,49(4): 268−271. doi: 10.3760/cma.j.issn.1006-7876.2016.04.002

    Parkinson's Disease and Movement Disorders Group of Neurology Branch of Chinese Medical Association, Professional Committee of Parkinson's Disease and Movement Disorders, Neurology Branch of Chinese Medical Doctor Association. Diagnostic criteria for Parkinson's disease in China (2016 edition)[J]. Chinese Journal of Neurology, 2016, 49(4): 268−271. (in Chinese). doi: 10.3760/cma.j.issn.1006-7876.2016.04.002
    [6]
    ARRIBARAT G, de BARROS A, PÉRAN P. Modern brainstem MRI techniques for the diagnosis of Parkinson's disease and parkinsonisms[J]. Front Neurology, 2020, 11: 791. doi: 10.3389/fneur.2020.00791
    [7]
    ANDICA C, KAMAGATA K, HATANO T, et al. MR biomarkers of degenerative brain disorders derived from diffusion imaging[J]. Journal of Magnetic Resonance Imaging, 2020, 52(6): 1620−1636. doi: 10.1002/jmri.27019
    [8]
    ARAB A, RUDA-KUCEROVA J, MINSTEROVA A, et al. Diffusion kurtosis imaging detects microstructural changes in a methamphetamine-induced mouse model of Parkinson's disease[J]. Neurotoxicity Research, 2019, 36(4): 724−735. doi: 10.1007/s12640-019-00068-0
    [9]
    JENSEN J H, HELPERN J A. MRI quantification of non-Gaussian water diffusion by kurtosis analysis[J]. NMR in Biomedicine, 2010, 23(7): 698−710. doi: 10.1002/nbm.1518
    [10]
    ITO K, OHTSUKA C, YOSHIOKA K, et al. Differential diagnosis of parkinsonism by a combined use of diffusion kurtosis imaging and quantitative susceptibility mapping[J]. Neuroradiology, 2017, 59(8): 759−769. doi: 10.1007/s00234-017-1870-7
    [11]
    孙亚琼, 张沁, 蒋震, 等. 帕金森病患者脑深部核团的磁共振扩散峰度成像分析及临床意义[J]. 中华医学杂志, 2017,97(45): 3534−3537. doi: 10.3760/cma.j.issn.0376-2491.2017.45.004

    SUN Y Q, ZHANG Q, JIANG Z, et al. Magnetic resonance diffusion kurtosis imaging analysis of deep brain nuclei in patients with Parkinson's disease and its clinical significance[J]. Chinese Medical Journal, 2017, 97(45): 3534−3537. (in Chinese). doi: 10.3760/cma.j.issn.0376-2491.2017.45.004
    [12]
    KAMAGATA K, ZALESKY A, HATANO T, et al. Gray matter abnormalities in idiopathic Parkinson's disease: Evaluation by diffusional kurtosis imaging and neurite orientation dispersion and density imaging[J]. Human Brain Mapping, 2017, 38(7): 3704−3722.
    [13]
    SUROVA Y, NILSSON M, LAMPINEN B, et al. Alteration of putaminal fractional anisotropy in Parkinson's disease: A longitudinal diffusion kurtosis imaging study[J]. Neuroradiology, 2018, 60(3): 247−254. doi: 10.1007/s00234-017-1971-3
    [14]
    胡达, 王波, 吴昆华, 等. DKI对震颤型帕金森患者脑深部核团微结构变化的诊断价值[J]. 放射学实践, 2020,35(8): 999−1004.

    HU D, WANG B, WU K H, et al. The value of DKI in the diagnosis of microstructural changes of deep brain nuclei in patients with tremor-type Parkinson's disease[J]. Radiology Practice, 2020, 35(8): 999−1004. (in Chinese).
    [15]
    KHAIRNAR A, LATTA P, DRAZANOVA E, et al. Diffusion kurtosis imaging detects microstructural alterations in brain of alpha-synuclein overexpressing transgenic mouse model of Parkinson's disease: A pilot study[J]. Neurotoxicity Research, 2015, 28(4): 281−289. doi: 10.1007/s12640-015-9537-9
    [16]
    HIRATA F C C, SATO J R, VIEIRA G, et al. Substantianigra fractional anisotropy is not a diagnosticbiomarker of Parkinson's disease: A diagnostic performance study and meta-analysis[J]. European Radiology, 2017, 27(6): 2640−2648. doi: 10.1007/s00330-016-4611-0
    [17]
    司海娜, 田玉玲, 王效春, 等. 不同运动亚型帕金森病患者脑深部核团扩散峰度成像的比较研究[J]. 中华神经科杂志, 2019,52(5): 379−386. doi: 10.3760/cma.j.issn.1006-7876.2019.05.004

    SI H N, TIAN Y L, WANG X C, et al. Comparative study of diffusion kurtosis imaging of deep nuclei in patients with different motor subtypes of Parkinson's disease[J]. Chinese Journal of Neurology, 2019, 52(5): 379−386. (in Chinese). doi: 10.3760/cma.j.issn.1006-7876.2019.05.004
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