ISSN 1004-4140
CN 11-3017/P
Volume 32 Issue 2
Mar.  2023
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ZHU J B, LI B, ZHANG H M, et al. Clinical Characteristics and Imaging features of Primary Orbital Lymphoma[J]. CT Theory and Applications, 2023, 32(2): 223-230. DOI: 10.15953/j.ctta.2022.245. (in Chinese).
Citation: ZHU J B, LI B, ZHANG H M, et al. Clinical Characteristics and Imaging features of Primary Orbital Lymphoma[J]. CT Theory and Applications, 2023, 32(2): 223-230. DOI: 10.15953/j.ctta.2022.245. (in Chinese).
shu

Clinical Characteristics and Imaging features of Primary Orbital Lymphoma

  • 1.

    Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University/Key Laboratory of Ophthalmology and Visual Science, Beijing 100730, China

  • 2.

    Department of Diagnostic Radiology, Cancer Hospital/Chinese Academy of Medical Sciences, National Cancer Center, Beijing 100021, China

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  • Received Date: December 05, 2022
  • Revised Date: December 26, 2022
  • Accepted Date: December 28, 2022
  • Available Online: January 08, 2023
  • Published Date: March 30, 2023
    Graphical Abstract
    • Abstract
  • Objective: To analyze the clinical characteristics and imaging features of primary orbital lymphoma in order to improve early diagnosis of the disease. Methods: Eighty-two patients were recruited from January 2015 to May 2022 who were diagnosed with orbital lymphomas via histopathology. The data on clinical characteristics, pathological subtypes, and imaging features for those patients were analyzed including symptoms, uni- or bilateral eye involvement, single or multiple lesions, tumor location, growth pattern, MRI signal intensity and MRI/CT enhancement patterns. Results: Eyelid swelling (52/82, 63.4%) and proptosis (43/82, 52.4%) were the two most common symptoms for primary orbital lymphomas, whose pathologic subtypes were mainly B-cell lymphomas, especially mucosa-associated lymphoid tissue lymphoma (60/82, 73.2%), and 59 cases (59/82, 72.0%) had unilateral eye involvement. Conjunctiva was the most common location (29/82, 35.4%), followed by eyelid (16/82, 19.5%) and muscle cone (11/82, 13.4%). Of the 66 cases who underwent MRI examinations, 60 showed iso-intensity on T1WI (90.9%), and 51 showed hyper-intensity on T2WI (77.3%). The tumors showed obvious enhancement on contrast-enhanced MRI or CT with 74.2% and 70.5%, respectively. Two other cases showed adjacent bone involvement on CT. Conclusion: B-cell lymphoma, especially mucosa-associated lymphoid tissue lymphoma was the most common primary orbital lymphoma subtype. The tumors mostly had unilateral eye involvement and the conjunctiva was the most common location. The typical imaging features were obvious enhancement on contrast-enhanced MRI or CT that would facilitate tumor diagnosis and treatment decision.
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    • References (18)
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