ISSN 1004-4140
CN 11-3017/P
ZHANG M X, LI L, SUN Y, et al. Comparative Analysis of Clinical and Computed Tomography Imaging Features of COVID-19 with Different Disease Courses[J]. CT Theory and Applications, 2023, 32(3): 380-386. DOI: 10.15953/j.ctta.2023.021. (in Chinese).
Citation: ZHANG M X, LI L, SUN Y, et al. Comparative Analysis of Clinical and Computed Tomography Imaging Features of COVID-19 with Different Disease Courses[J]. CT Theory and Applications, 2023, 32(3): 380-386. DOI: 10.15953/j.ctta.2023.021. (in Chinese).

Comparative Analysis of Clinical and Computed Tomography Imaging Features of COVID-19 with Different Disease Courses

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  • Received Date: February 13, 2023
  • Revised Date: March 07, 2023
  • Accepted Date: March 08, 2023
  • Available Online: April 22, 2023
  • Published Date: May 30, 2023
  • Objective: To compare and analyze the clinical and chest computed tomography (CT) imaging features of COVID-19 patients with different disease courses. Methods: A retrospective analysis was performed for 161 cases with confirmed COVID-19 and positive chest CT lung infections from December 2022 to January 2023 at the fever clinic of Beijing Shijitan Hospital affiliated with Capital Medical University. The patients were divided into two groups based on the time of CT examination: <10 days and ≥10 days. We statistically analyzed the clinical manifestations and chest CT imaging characteristics of the two groups. Results: Of the 161 cases, 92 cases (57.1%) were in the <10-day group, and 69 cases (42.9%) were in the ≥10-day group. The clinical symptoms of the two groups showed that there was a statistical difference in the proportion of sore throat and myalgia between the two groups. Laboratory indicators showed that the C-reactive protein and lymphocyte count were significantly higher in the <10-day group. In terms of CT imaging features, the proportion of patients with perivascular, mixed distribution, large area, and air bronchogram was higher in the patients from the <10-day group, while the patients in the ≥10-day group had a significantly higher proportion of irregular boundaries, intralesional cord, reversed halo sign, pleural tail sign, subpleural line, and subpleural palisade. Conclusion: The clinical symptoms, laboratory indexes, and CT imaging features of COVID-19 pulmonary infection differed depending on the disease course, and exploring these differences can help clinicians diagnose and treat COVID-19 lung infections more effectively.
  • [1]
    WHO Coronavirus (COVID-19) Dashboard. Worle health organization[EB/OL]. [2023-02]. https://covid19.who.int.
    [2]
    YE Z, ZHANG Y, WANG Y, et al. Chest CT manifestations of new coronavirus disease 2019 (COVID-19): A pictorial review[J]. European Radiology, 2020, 30(8): 4381−4389.
    [3]
    SINGANAYAGAM A, PATEL M, CHARLETT A, et al. Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020[J]. European Surveillance, 2020, 25(32): 2001483.
    [4]
    李华侨, 陈建新, 黄云华, 等. 新型冠状病毒肺炎患者临床及CT影像特点分析[J]. 国际病毒学杂志, 2022,29(1): 1−4. DOI: 10.3760/cma.j.issn.1673-4092.2022.01.001.

    LI H J, CHEN J X, HUANG Y H, et al. Ananalysis on clinical and CT imaging features of COVID-19 patients[J]. International Journal of Virology, 2022, 29(1): 1−4. DOI: 10.3760/cma.j.issn.1673-4092.2022.01.001. (in Chinese).
    [5]
    SMILOWITZ N R, KUNICHOFF D, GARSHICK M, et al. C-reactive protein and clinical outcomes in patients with COVID-19[J]. European Heart Journal, 2021, 42(23): 2270−2279. DOI: 10.1093/eurheartj/ehaa1103.
    [6]
    VOLANAKIS J E. Human C-reactive protein: Expression, structure, and function[J]. Molecular Immunology, 2001, 38(2/3): 189−197.
    [7]
    LENTNER J, ADAMS T, KNUTSON V, et al. C-reactive protein levels associated with COVID-19 outcomes in the United States[J]. Journal of Osteopathic Medicine, 2021, 121(12): 869−873. doi: 10.1515/jom-2021-0103
    [8]
    PONTI G, MACCAFERRI M, RUINI C, et al. Biomarkers associated with COVID-19 disease progression[J]. Critical Reviews in Clinical Laboratory Sciences, 2020, 57(6): 389−399. doi: 10.1080/10408363.2020.1770685
    [9]
    陈婉玲, 王伟峰, 李文涛, 等. COVID-19患者外周血T淋巴细胞计数动态变化研究[J]. 中华微生物学和免疫学杂志, 2020,40(7): 495−498. DOI: 10.3760/cma.j.cn112309-20200301-00089.

    CHEN W L, WANG W F, LI W T, et al. Dynamic changes of peripheral blood T lymphocytes in COVID-19 patients[J]. Chinese Journal of Microbiology and Immunology, 2020, 40(7): 495−498. DOI: 10.3760/cma.j.cn112309-20200301-00089. (in Chinese).
    [10]
    LIU C, CAI J, ZHANG M, et al. Clinical characteristics and CT imaging features of COVID-19 on admission: A retrospective study[J]. Current Medical Imaging, 2021, 17(11): 1324−1329.
    [11]
    XU X, CHEN P, WANG J, et al. Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission[J]. Science China Life Sciences, 2020, 63(3): 457−460. doi: 10.1007/s11427-020-1637-5
    [12]
    BATAH S S, FABRO A T. Pulmonary pathology of ARDS in COVID-19: A pathological review for clinicians[J]. Respiratory Medicine, 2021, 176: 106239. doi: 10.1016/j.rmed.2020.106239
    [13]
    YAO X H, LUO T, SHI Y, et al. A cohort autopsy study defines COVID-19 systemic pathogenesis[J]. Cell Research., 2021, 31(8): 836−846. doi: 10.1038/s41422-021-00523-8
    [14]
    HANSELL D M, BANKIER A A, Mac MAHON H, et al. Fleischner Society: Glossary of terms for thoracic imaging[J]. Radiology, 2008, 246(3): 697−722. doi: 10.1148/radiol.2462070712
    [15]
    HUANG P, LIU T, HUANG L, et al. Use of chest CT in combination with negative RT-PCR assay for the 2019 novel coronavirus but high clinical suspicion[J]. Radiology, 2020, 295(1): 22−23. doi: 10.1148/radiol.2020200330
    [16]
    KONG W, AGARWAL P P. Chest imaging appearance of COVID-19 infection[J]. Radiology Cardiothoracic Imaging, 2020, 2(1): e200028. doi: 10.1148/ryct.2020200028
    [17]
    PAN Y, GUAN H, ZHOU S, et al. Initial CT findings and temporal changes in patients with the novel coronavirus pneumonia (2019-nCoV): A study of 63 patients in Wuhan, China[J]. European Radiology, 2020, 30(6): 3306−3309. doi: 10.1007/s00330-020-06731-x
    [18]
    PAN F, YE T, SUN P, et al. Time course of lung changes at chest CT during recovery from coronavirus disease 2019 (COVID-19)[J]. Radiology, 2020, 295(3): 715−721. doi: 10.1148/radiol.2020200370
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