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WANG S B, LING S Q, PAN Y, et al. Evaluation of WHO/ISUP Pathological Grading of Clear Cell Renal Cell Carcinoma by CT-based Extracellular Volume Fraction[J]. CT Theory and Applications, xxxx, x(x): 1-6. DOI: 10.15953/j.ctta.2025.011. (in Chinese).
Citation: WANG S B, LING S Q, PAN Y, et al. Evaluation of WHO/ISUP Pathological Grading of Clear Cell Renal Cell Carcinoma by CT-based Extracellular Volume Fraction[J]. CT Theory and Applications, xxxx, x(x): 1-6. DOI: 10.15953/j.ctta.2025.011. (in Chinese).
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Evaluation of WHO/ISUP Pathological Grading of Clear Cell Renal Cell Carcinoma by CT-based Extracellular Volume Fraction

  • a.

    Huangshan City People’s Hospital, Huangshan 245000,China Department of CT/MRI

  • b.

    Huangshan City People’s Hospital, Huangshan 245000,China Department of Pathology

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  • Received Date: January 04, 2025
  • Revised Date: January 25, 2025
  • Accepted Date: February 04, 2025
  • Available Online: March 04, 2025
    Graphical Abstract
    • Abstract

  • Objective: To investigate the value of computed tomography-based extracellular volume fraction (ECV) for preoperative evaluation of WHO/ISUP pathologic grading of clear cell renal cell carcinoma (ccRCC). Methods: Seventy-two patients with ccRCC who underwent postoperative histological confirmation were retrospectively enrolled. All patients underwent preoperative CT scanning of the abdomen and three-phase enhancement scanning according to the WHO/ISUP grading. Grades I and II were categorized as the low-grade group (48 patients) and grades III and IV were categorized as the high-grade group (19 patients). General clinical data of the two groups were collected, and quantitative parameters, including delayed aortic net value added (∆HUAorta ), delayed tumor net value added (∆HUtumor)and ECV, were measured and compared, and the diagnostic efficacy of ECV in the pathological grading of ccRCC was evaluated by plotting the ROC curve. Results: The ∆HUtumor and ECV of ccRCC in low-grade group were significantly higher than those in high-grade group (P<0.05). The ROC curves demonstrated that the efficiency of ECV in evaluating WHO/ISUP low-grade ccRCC (AUC: 0.834) was higher than that of ∆HUtumor(AUC:0.725). Conclusion: CT-based ECV is valuable for the preoperative evaluation of ccRCC pathological grade.

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