The Application Study of Different BSA Normalization Methods in the Evaluation of GFR by Gate's in Elder Patients

Objective: To compare the application value of different BSA normalization methods in the evaluation of GFR by Gate's in elder patients. Methods: The clinical data of 91 cases of patients who performed double plasma clearance method (tGFR₀) and renography examination (gGFR₀) were selected in our study. According to different formulas (DuBois formula, Gehan and Georgeformula, Stevensonformula, Flu Yongmei formula, Hu Yongmei-gender correction formula), the GFR_1-5 were calculated. The correlation of tGFRx and gGFRx were analyzed. The patients were divided into two subgroups according to BMI (group a and group b), and gGFR were recorded as gGFRx-a and gGFRx-b and its correlation with tGFRx-a or tGFRx-b were analyzed. Results: The correlation of tGFR and gGFR was good in whole study cohort, and r_5-a=0.841, which was highest among all paired groups (P<0.05). The correlation of tGFR and gGFR in group b was worse (P<0.05). Conclusion: The evaluation of GFR by Gate's method is well correlated with tGFR, but it is still a difficult clinical question for the GFR evaluation of fat patients, which needs a large sample size of validation.